{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T13:23:20Z","timestamp":1790688200461,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,5,2]],"date-time":"2012-05-02T00:00:00Z","timestamp":1335916800000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:p>Nusslock R, Almeida JRC, Forbes EE, Versace A, Frank E, LaBarbara EJ, Klein CR, Phillips ML. Waiting to win: elevated striatal and orbitofrontal cortical activity during reward anticipation in euthymic bipolar disorder adults. Bipolar Disord 2012: 14: 249\u2013260. \u00a9 2012 The Authors. Journal compilation \u00a9 2012 John Wiley &amp; Sons A\/S.<\/jats:p><jats:p><jats:bold>Objective:\u2002<\/jats:bold> Bipolar disorder may be characterized by a hypersensitivity to reward\u2010relevant stimuli, potentially underlying the emotional lability and dysregulation that characterizes the illness. In parallel, research highlights the predominant role of striatal and orbitofrontal cortical (OFC) regions in reward\u2010processing and approach\u2010related affect. We aimed to examine whether bipolar disorder, relative to healthy, participants displayed elevated activity in these regions during reward processing.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Twenty\u2010one euthymic bipolar I disorder and 20 healthy control participants with no lifetime history of psychiatric disorder underwent functional magnetic resonance imaging (fMRI) scanning during a card\u2010guessing paradigm designed to examine reward\u2010related brain function to anticipation and receipt of monetary reward and loss. Data were collected using a 3T Siemens Trio scanner.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Region\u2010of\u2010interest analyses revealed that bipolar disorder participants displayed greater ventral striatal and right\u2010sided orbitofrontal [Brodmann area (BA) 11] activity during anticipation, but not outcome, of monetary reward relative to healthy controls (p\u2003&lt;\u20030.05, corrected). Whole\u2010brain analyses indicated that bipolar disorder, relative to healthy, participants also displayed elevated left\u2010lateral OFC (BA 47) activity during reward anticipation (p\u2003&lt;\u20030.05, corrected).<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Elevated ventral striatal and OFC activity during reward anticipation may represent a neural mechanism for predisposition to expansive mood and hypo\/mania in response to reward\u2010relevant cues that characterizes bipolar disorder. Our findings contrast with research reporting blunted activity in the ventral striatum during reward processing in unipolar depressed individuals, relative to healthy controls. Examination of reward\u2010related neural activity in bipolar disorder is a promising research focus to facilitate identification of biological markers of the illness.<\/jats:p>","DOI":"10.1111\/j.1399-5618.2012.01012.x","type":"journal-article","created":{"date-parts":[[2012,5,2]],"date-time":"2012-05-02T11:04:25Z","timestamp":1335956665000},"page":"249-260","source":"Crossref","is-referenced-by-count":199,"title":["Waiting to win: elevated striatal and orbitofrontal cortical activity during reward anticipation in euthymic bipolar disorder adults"],"prefix":"10.1111","volume":"14","author":[{"given":"Robin","family":"Nusslock","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge RC","family":"Almeida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika E","family":"Forbes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amelia","family":"Versace","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Frank","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edmund J","family":"LaBarbara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Crystal R","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary L","family":"Phillips","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,5,2]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(01)00377-9"},{"key":"e_1_2_7_3_2","volume-title":"Manic\u2010depressive Illness: Bipolar Disorders and Recurrent Depression","author":"Goodwin FK","year":"2007"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v64n0209"},{"key":"e_1_2_7_5_2","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1176\/ajp.2006.163.7.1135","article-title":"Redefining bipolar disorder: toward DSM\u2010V","volume":"163","author":"Phillips ML","year":"2006","journal-title":"Am J Psychiatry"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2008.04.004"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1022119414440"},{"key":"e_1_2_7_8_2","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1023\/A:1010929402770","article-title":"Responsiveness to threat and incentive in bipolar disorder: relations of the BIS\/BAS scales with symptoms","volume":"23","author":"Meyer B","year":"2001","journal-title":"J Psychopathol Behavior Assess"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2007.00547.x"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1037\/0021-843X.109.4.721"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1037\/0021-843X.116.1.105"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00491-3"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2000.84.6.3072"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/13.3.308"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2009.129"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-8119(02)00057-5"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20909"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2007.08.004"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2008.07081336"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jadohealth.2009.04.001"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00303-8"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1037\/a0019533"},{"key":"e_1_2_7_23_2","volume-title":"Structured Clinical Interview for DSM\u2010IV Axis I Disorders\u2010patient Edition (SCID\u2010I\/P, Version 2.0)","author":"First MB","year":"1995"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v67n0211"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1990.03450190043026"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2007.07071066"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1080\/13854048908403285"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2008.00641.x"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2009.09.027"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhn041"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhj088"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-8119(03)00169-1"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5499-10.2011"},{"key":"e_1_2_7_35_2","first-page":"449","article-title":"Psychosocial interventions for bipolar disorder: perspective from the Behavioral Approach System (BAS) dysregulation theory","volume":"16","author":"Nusslock R","year":"2009","journal-title":"Clin Psychol"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2008.08081201"},{"key":"e_1_2_7_37_2","doi-asserted-by":"publisher","DOI":"10.1111\/1469-8986.00067"},{"key":"e_1_2_7_38_2","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1176\/ajp.2006.163.10.1784","article-title":"Lack of ventral striatal response to positive stimuli in depressed versus normal subjects","volume":"163","author":"Epstein J","year":"2006","journal-title":"Am J Psychiatry"},{"key":"e_1_2_7_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2004.10.028"},{"key":"e_1_2_7_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2009.04.035"},{"key":"e_1_2_7_41_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1301620"}],"container-title":["Bipolar Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1399-5618.2012.01012.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1399-5618.2012.01012.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T00:29:32Z","timestamp":1698712172000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1399-5618.2012.01012.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,5]]}},"alternative-id":["10.1111\/j.1399-5618.2012.01012.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1399-5618.2012.01012.x","archive":["Portico"],"relation":{},"ISSN":["1398-5647","1399-5618"],"issn-type":[{"value":"1398-5647","type":"print"},{"value":"1399-5618","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5]]}}}