{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T15:09:16Z","timestamp":1777561756486,"version":"3.51.4"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,5,25]],"date-time":"2012-05-25T00:00:00Z","timestamp":1337904000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:p>Townsend JD, Bookheimer SY, Foland\u2010Ross LC, Moody TD, Eisenberger NI, Fischer JS, Cohen MS, Sugar CA, Altshuler LL. Deficits in inferior frontal cortex activation in euthymic bipolar disorder patients during a response inhibition task. \u2028Bipolar Disord 2012: 14: 442\u2013450. \u00a9 2012 The Authors. Journal compilation \u00a9 2012 John Wiley &amp; Sons A\/S.<\/jats:p><jats:p><jats:bold>Objectives:\u2002<\/jats:bold> The inferior frontal cortical\u2013striatal network plays an integral role in response inhibition in normal populations. While inferior frontal cortex (IFC) impairment has been reported in mania, this study explored whether this dysfunction persists in euthymia.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Functional magnetic resonance imaging (fMRI) activation was evaluated in 32 euthymic patients with bipolar I disorder and 30 healthy subjects while performing the Go\/NoGo response inhibition task. Behavioral data were collected to evaluate accuracy and response time. Within\u2010group and between\u2010group comparisons of activation were conducted using whole\u2010brain analyses to probe significant group differences in neural function.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Both groups activated bilateral IFC. However, between\u2010group comparisons showed a significantly reduced activation in this brain region in euthymic patients with bipolar disorder compared to healthy subjects. Other frontal and basal ganglia regions involved in response inhibition were additionally significantly reduced in bipolar disorder patients, in both the medicated and the unmedicated subgroups. No areas of greater activation were observed in bipolar disorder patients versus healthy subjects.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Bipolar disorder patients, even during euthymia, have a persistent reduction in activation of brain regions involved in response inhibition, suggesting that reduced activation in the orbitofrontal cortex and striatum is not solely related to the state of mania. These findings may represent underlying trait abnormalities in bipolar disorder.<\/jats:p>","DOI":"10.1111\/j.1399-5618.2012.01020.x","type":"journal-article","created":{"date-parts":[[2012,5,25]],"date-time":"2012-05-25T15:19:19Z","timestamp":1337959159000},"page":"442-450","source":"Crossref","is-referenced-by-count":76,"title":["Deficits in inferior frontal cortex activation in euthymic bipolar disorder patients during a response inhibition task"],"prefix":"10.1111","volume":"14","author":[{"given":"Jennifer D","family":"Townsend","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan Y","family":"Bookheimer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lara C","family":"Foland\u2010Ross","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teena 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