{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T02:54:36Z","timestamp":1792637676922,"version":"4.5.0"},"reference-count":72,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,5,25]],"date-time":"2012-05-25T00:00:00Z","timestamp":1337904000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:p>Strakowski SM, Adler CM, Almeida J, Altshuler LL, Blumberg HP, Chang KD, DelBello MP, Frangou S, McIntosh A, Phillips ML, Sussman JE, Townsend JD. The functional neuroanatomy of bipolar disorder: a consensus model. \u2028Bipolar Disord 2012: 14: 313\u2013325. \u00a9 2012 The Authors. Journal compilation \u00a9 2012 John Wiley &amp; Sons A\/S.<\/jats:p>\n                  <jats:p>\n                    <jats:bold>Objectives:\u2002<\/jats:bold>\n                    Functional neuroimaging methods have proliferated in recent years, such that functional magnetic resonance imaging, in particular, is now widely used to study bipolar disorder. However, discrepant findings are common. A workgroup was organized by the Department of Psychiatry, University of Cincinnati (Cincinnati, OH, USA) to develop a consensus functional neuroanatomic model of bipolar I disorder based upon the participants\u2019 work as well as that of others.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:\u2002<\/jats:bold>\n                    Representatives from several leading bipolar disorder neuroimaging groups were organized to present an overview of their areas of expertise as well as focused reviews of existing data. The workgroup then developed a consensus model of the functional neuroanatomy of bipolar disorder based upon these data.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:\u2002<\/jats:bold>\n                    Among the participants, a general consensus emerged that bipolar I disorder arises from abnormalities in the structure and function of key emotional control networks in the human brain. Namely, disruption in early development (e.g., white matter connectivity and prefrontal pruning) within brain networks that modulate emotional behavior leads to decreased connectivity among ventral prefrontal networks and limbic brain regions, especially the amygdala. This developmental failure to establish healthy ventral prefrontal\u2013limbic modulation underlies the onset of mania and ultimately, with progressive changes throughout these networks over time and with affective episodes, a bipolar course of illness.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:\u2002<\/jats:bold>\n                    This model provides a potential substrate to guide future investigations and areas needing additional focus are identified.\n                  <\/jats:p>","DOI":"10.1111\/j.1399-5618.2012.01022.x","type":"journal-article","created":{"date-parts":[[2012,5,25]],"date-time":"2012-05-25T11:19:19Z","timestamp":1337944759000},"page":"313-325","source":"Crossref","is-referenced-by-count":462,"title":["The functional neuroanatomy of bipolar disorder: a consensus model"],"prefix":"10.1111","volume":"14","author":[{"given":"Stephen M","family":"Strakowski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caleb M","family":"Adler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Almeida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori L","family":"Altshuler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilary P","family":"Blumberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiki D","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa P","family":"DelBello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia","family":"Frangou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"McIntosh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary L","family":"Phillips","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessika E","family":"Sussman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer D","family":"Townsend","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,5,25]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2012.01021.x"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2012.01015.x"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2012.01024.x"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2012.01023.x"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2012.01016.x"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2012.01018.x"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2012.01020.x"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2012.01019.x"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2012.01014.x"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.182176499"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00230650"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1162\/089892998562924"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2002.1087"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2011.00893.x"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.154.7.926"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2008.82"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/med\/9780199797608.003.0109"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.162.6.1211"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200001170-00009"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/CHI.0b013e31819f6fbc"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-005-0156-7"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2009.09.027"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2003.11.017"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0603246103"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300492"},{"key":"e_1_2_8_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2008.00617.x"},{"key":"e_1_2_8_28_2","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1093\/med\/9780199797608.003.0032","volume-title":"The Bipolar Brain: Integrating Neuroimaging and Genetics","author":"Altshuler LL","year":"2012"},{"key":"e_1_2_8_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2010.09.019"},{"key":"e_1_2_8_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2011.04.007"},{"key":"e_1_2_8_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2007.04.007"},{"key":"e_1_2_8_32_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-5618.2000.20304.x"},{"key":"e_1_2_8_33_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.60.6.601"},{"key":"e_1_2_8_34_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2006.00282.x"},{"key":"e_1_2_8_35_2","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1176\/ajp.156.12.1986","article-title":"Rostral and orbital prefrontal cortex dysfunction in the manic state of bipolar disorder","volume":"156","author":"Blumberg HP","year":"1999","journal-title":"Am J Psychiatry"},{"key":"e_1_2_8_36_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2004.00117.x"},{"key":"e_1_2_8_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2010.04.002"},{"key":"e_1_2_8_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2009.04.015"},{"key":"e_1_2_8_39_2","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1093\/med\/9780199797608.003.0057","volume-title":"The Bipolar Brain: Integrating Neuroimaging and Genetics","author":"Versace A","year":"2012"},{"key":"e_1_2_8_40_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.163.2.322"},{"key":"e_1_2_8_41_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2007.00482.x"},{"key":"e_1_2_8_42_2","first-page":"1249","article-title":"Altered development of white matter in youth at high familial risk for bipolar disorder: a diffusion tensor imaging study","volume":"49","author":"Versace A","year":"2010","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"e_1_2_8_43_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.159.11.1841"},{"key":"e_1_2_8_44_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.65.9.1041"},{"key":"e_1_2_8_45_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2010.00874.x"},{"key":"e_1_2_8_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1364-6613(00)01483-2"},{"key":"e_1_2_8_47_2","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1176\/ajp.156.5.675","article-title":"Reciprocal limbic\u2010cortical function and negative mood: converging PET findings in depression and normal sadness","volume":"156","author":"Mayberg HS","year":"1999","journal-title":"Am J Psychiatry"},{"key":"e_1_2_8_48_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-7893.2008.00082.x"},{"key":"e_1_2_8_49_2","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.2007.164.4.638"},{"key":"e_1_2_8_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2007.03.003"},{"key":"e_1_2_8_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2009.03.023"},{"key":"e_1_2_8_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2007.10.003"},{"key":"e_1_2_8_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2003.10.010"},{"key":"e_1_2_8_54_2","volume-title":"Manic\u2010Depressive Illness: Bipolar Disorders and Recurrent Depression","author":"Goodwin FK","year":"2007"},{"key":"e_1_2_8_55_2","doi-asserted-by":"publisher","DOI":"10.2165\/11539700-000000000-00000"},{"key":"e_1_2_8_56_2","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1093\/med\/9780199797608.003.0050","volume-title":"The Bipolar Brain: Integrating Neuroimaging and Genetics","author":"Singh MK","year":"2012"},{"key":"e_1_2_8_57_2","doi-asserted-by":"publisher","DOI":"10.1097\/CHI.0b013e318167655a"},{"key":"e_1_2_8_58_2","doi-asserted-by":"publisher","DOI":"10.1097\/CHI.0b013e318167656e"},{"key":"e_1_2_8_59_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-199203000-00012"},{"key":"e_1_2_8_60_2","doi-asserted-by":"publisher","DOI":"10.1053\/comp.2002.34636"},{"key":"e_1_2_8_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2007.10.006"},{"key":"e_1_2_8_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2011.01.021"},{"key":"e_1_2_8_63_2","doi-asserted-by":"publisher","DOI":"10.1097\/CHI.0b013e3181900421"},{"key":"e_1_2_8_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2009.02.025"},{"key":"e_1_2_8_65_2","doi-asserted-by":"publisher","DOI":"10.1097\/CHI.0b013e318185d299"},{"key":"e_1_2_8_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaac.2011.07.001"},{"key":"e_1_2_8_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2010.08.029"},{"key":"e_1_2_8_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2005.08.031"},{"key":"e_1_2_8_69_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617709090584"},{"key":"e_1_2_8_70_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2004.00178.x"},{"key":"e_1_2_8_71_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7610.2007.01747.x"},{"key":"e_1_2_8_72_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature06976"},{"key":"e_1_2_8_73_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.62.8.851"}],"container-title":["Bipolar Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1399-5618.2012.01022.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1399-5618.2012.01022.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T03:25:22Z","timestamp":1698722722000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1399-5618.2012.01022.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5,25]]},"references-count":72,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["10.1111\/j.1399-5618.2012.01022.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1399-5618.2012.01022.x","archive":["Portico"],"relation":{},"ISSN":["1398-5647","1399-5618"],"issn-type":[{"value":"1398-5647","type":"print"},{"value":"1399-5618","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5,25]]}}}