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Bipolar Disord 2012: 14: 554\u2013564. \u00a9 2012 The Authors. \u2028Journal compilation \u00a9 2012 John Wiley &amp; Sons A\/S.<\/jats:p><jats:p><jats:bold>Objective:\u2002<\/jats:bold> The dopaminergic system plays an important role in the prefrontal cortex (PFC) and is believed to mediate cognitive dysfunction (CD) in bipolar disorder (BD). The enzyme catechol\u2010<jats:italic>O<\/jats:italic>\u2010methyltransferase (COMT) is involved in the catabolism of dopamine in the PFC, and an association between COMT single nucleotide polymorphisms (SNPs) and BD has been reported. COMT SNPs have also been associated with executive and working memory performance in healthy subjects, patients with schizophrenia, and euthymic BD patients. The objective of this study was to investigate the association between COMT SNPs and acute CD during BD mood episodes.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Seventy\u2010two symptomatic, medication\u2010free subjects with bipolar I disorder (BD\u2010I) and 76 healthy controls were evaluated using neuropsychological tests, and genotyped for COMT SNPs rs4680 and rs165599.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Patients undergoing mania and mixed episodes carrying the COMT allele G had better performance on executive function, memory, verbal fluency, and intelligence tests. Moreover, an interaction was detected between the COMT allele G and the Young Mania Rating Scale in BD CD.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Allele G from COMT SNPs rs4680 and rs165599 may represent reliable state\u2010dependent predictors of global CD during manic and mixed episodes in BD. Further studies in larger samples are necessary to confirm these findings.<\/jats:p>","DOI":"10.1111\/j.1399-5618.2012.01030.x","type":"journal-article","created":{"date-parts":[[2012,6,19]],"date-time":"2012-06-19T16:17:37Z","timestamp":1340122657000},"page":"554-564","source":"Crossref","is-referenced-by-count":22,"title":["COMT polymorphisms as predictors of cognitive dysfunction during manic and mixed episodes in bipolar I disorder"],"prefix":"10.1111","volume":"14","author":[{"given":"M\u00e1rcio Gerhardt","family":"Soeiro\u2010de\u2010Souza","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo","family":"Machado\u2010Vieira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle","family":"Soares Bio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina Martins","family":"Do 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