{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:10:06Z","timestamp":1787508606548,"version":"build-2736575974"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,7,20]],"date-time":"2012-07-20T00:00:00Z","timestamp":1342742400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:p>Fiedorowicz JG, Endicott J, Solomon DA, Keller MB, Coryell WH. Course of illness following prospectively observed mania or hypomania in individuals presenting with unipolar depression. Bipolar Disord 2012: 14: 664\u2013671. \u00a9 2012 The Authors. Journal compilation \u00a9 2012 John Wiley &amp; Sons A\/S.<\/jats:p>\n                  <jats:p>\n                    <jats:bold>Objectives:\u2002<\/jats:bold>\n                    In a well\u2010defined sample, we sought to determine which clinical variables, some of potential nosological relevance, influence subsequent course following prospectively observed initial episodes of hypomania or mania (H\/M).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:\u2002<\/jats:bold>\n                    We identified 108 individuals in the National Institute of Mental Health Collaborative Depression Study diagnosed with unipolar major depression at intake who subsequently developed H\/M. We assessed time to repeat H\/M based on whether one had been started on an antidepressant or electroconvulsive therapy within eight weeks of developing H\/M, had longer episodes, or had a family history of bipolar disorder.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:\u2002<\/jats:bold>\n                    Modeling age of onset, treatment\u2010associated H\/M, family history of bipolar disorder, duration of index H\/M episode, and psychosis in Cox regression analysis, family history of bipolar disorder (n\u2003=\u200321) was strongly associated with repeat episodes of H\/M [hazard ratio (HR)\u2003=\u20032.01, 95% confidence interval (CI): 1.06\u20133.83, p\n                    <jats:italic>\u2003<\/jats:italic>\n                    =\u20030.03]. Those with treatment\u2010associated episodes (n\u2003=\u200312) were less likely to experience subsequent episodes of H\/M, although this was not significant in the multivariate model (HR\u2003=\u20030.25, 95% CI: 0.06\u20131.05, p\u2003=\u20030.06). These individuals also had a later age of onset for affective illness and were more likely to be depressed. Duration of illness with a temporal resolution of one\u2003week, psychosis, and age of onset were not associated with time to repeat H\/M episode.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:\u2002<\/jats:bold>\n                    A family history of bipolar disorder influences the course of illness, even after an initial H\/M episode. In this select sample, treatment\u2010associated H\/M did not appear to convey the same risk for a course of illness characterized by recurrent H\/M episodes.\n                  <\/jats:p>","DOI":"10.1111\/j.1399-5618.2012.01041.x","type":"journal-article","created":{"date-parts":[[2012,7,20]],"date-time":"2012-07-20T21:06:01Z","timestamp":1342818361000},"page":"664-671","source":"Crossref","is-referenced-by-count":18,"title":["Course of illness following prospectively observed mania or hypomania in individuals presenting with unipolar depression"],"prefix":"10.1111","volume":"14","author":[{"given":"Jess G","family":"Fiedorowicz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Endicott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A","family":"Solomon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin B","family":"Keller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William H","family":"Coryell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,7,20]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1399-5618.2003.00067.x"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0447.2002.02360.x"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.152.8.1130"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-004-1948-x"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v67n0903"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.06.010"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v63n0907"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ypg.0000180684.26288.d7"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2006.01.028"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.tpj.6500156"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-199612000-00003"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v62n0406"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1982.04290050029007"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1979.01780060025002"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0327(83)90004-6"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.jcp.0000237950.65517.be"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(02)00325-7"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1978.01770310043002"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.136.1.52"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2010.10030328"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1987.01800180050009"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/PSY.0b013e3181acee26"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291708004078"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1994.tb01495.x"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2011.05.019"},{"key":"e_1_2_7_27_2","unstructured":"American Psychiatric Association.Proposed Revision: Manic Episode.2010. 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