{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:46:33Z","timestamp":1791305193853,"version":"4.3.1"},"reference-count":68,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,9,3]],"date-time":"2012-09-03T00:00:00Z","timestamp":1346630400000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:p>Singh MK, Chang KD, Chen MC, Kelley RG, Garrett A, Mitsunaga MM, Bararpour L, Howe M, Reiss AL, Gotlib IH. Volumetric reductions in the subgenual anterior cingulate cortex in adolescents with bipolar I disorder. \u2028Bipolar Disord 2012: 14: 585\u2013596. \u00a9 2012 The Authors. \u2028Journal compilation \u00a9 2012 John Wiley &amp; Sons A\/S.<\/jats:p><jats:p><jats:bold>Objectives:\u2002<\/jats:bold> A range of prefrontal and subcortical volumetric abnormalities have been found in adults and adolescents with bipolar disorder. It is unclear, however, if these deficits are present early in the onset of mania or are a consequence of multiple mood episodes or prolonged exposure to medication. The goal of this study was to examine whether youth with bipolar I disorder who recently experienced their first episode of mania are characterized by brain volumetric abnormalities.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Anatomical images from magnetic resonance imaging of 26 13\u2010 to 18\u2010year\u2010old adolescents with bipolar I disorder and 24 age\u2010comparable healthy controls with no personal or family history of psychopathology were analyzed using whole\u2010brain voxel\u2010based morphometry (VBM).<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Compared with healthy controls, adolescents with bipolar I disorder had significantly less gray matter volume in the left subgenual cingulate cortex [p\u2003&lt;\u20030.05, family\u2010wise error (FWE)\u2010corrected].<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Adolescents with a recent single episode of mania have smaller subgenual cingulate cortex volume than do their healthy counterparts, suggesting that this anomaly occurs early in the onset of, or may predate the disorder. Longitudinal studies are needed to examine the impact of this volumetric reduction on the course and outcome of this disorder.<\/jats:p>","DOI":"10.1111\/j.1399-5618.2012.01043.x","type":"journal-article","created":{"date-parts":[[2012,9,3]],"date-time":"2012-09-03T09:17:16Z","timestamp":1346663836000},"page":"585-596","source":"Crossref","is-referenced-by-count":41,"title":["Volumetric reductions in the subgenual anterior cingulate cortex in adolescents with bipolar I disorder"],"prefix":"10.1111","volume":"14","author":[{"given":"Manpreet K","family":"Singh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiki D","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael C","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan G","family":"Kelley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Garrett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myles M","family":"Mitsunaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Layla","family":"Bararpour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meghan","family":"Howe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan L","family":"Reiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian H","family":"Gotlib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,9,3]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2008.82"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-009-0073-2"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2005.11.016"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2007.04.003"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-010-0151-5"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.108.059717"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.05.042"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.07.035"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-7893.2008.00071.x"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.08m04580"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.159.11.1841"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2009.00759.x"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2004.01.022"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/CHI.0b013e318167655a"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1089\/cap.2010.0096"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2010.00806.x"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2004.02.026"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2004.07.020"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh274"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.09.029"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.62.7.734"},{"key":"e_1_2_7_23_2","volume-title":"Washington University at St. Louis Kiddie and Young Adult Schedule for Affective Disorders and Schizophrenia (WASH\u2010U\u2010KSADS)","author":"Geller B","year":"1996"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-199707000-00021"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.133.5.429"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.64.4.442"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1983.01790100074010"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4679(199511)51:6<768::AID-JCLP2270510607>3.0.CO;2-1"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/0148-9062(75)90418-0"},{"key":"e_1_2_7_30_2","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1542\/peds.66.6.918","article-title":"Adolescents\u2019 self\u2010assessment of sexual maturation","volume":"66","author":"Duke PM","year":"1980","journal-title":"Pediatrics"},{"key":"e_1_2_7_31_2","volume-title":"Wechsler Abbreviated Scale of Intelligence","author":"Wechsler D","year":"1999"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.2307\/1419611"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.02.018"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2000.0582"},{"key":"e_1_2_7_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.07.007"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.162.9.1706"},{"key":"e_1_2_7_37_2","unstructured":"GaserC.Non\u2010Stationary Cluster Extent Correction. Available from:http:\/\/dbm.neuro.uni\u2010jena.de\/vbm\/[accessed December 2009]."},{"key":"e_1_2_7_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.460020402"},{"key":"e_1_2_7_39_2","doi-asserted-by":"publisher","DOI":"10.1093\/scan\/nsp052"},{"key":"e_1_2_7_40_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.107.049205"},{"key":"e_1_2_7_41_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.162.9.1637"},{"key":"e_1_2_7_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2007.04.019"},{"key":"e_1_2_7_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2004.01.004"},{"key":"e_1_2_7_44_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0402680101"},{"key":"e_1_2_7_45_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhn117"},{"key":"e_1_2_7_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4000370"},{"key":"e_1_2_7_47_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7610.2007.01747.x"},{"key":"e_1_2_7_48_2","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1176\/ajp.156.7.1091","article-title":"Subgenual cingulate cortex volume in first\u2010episode psychosis","volume":"156","author":"Hirayasu Y","year":"1999","journal-title":"Am J Psychiatry"},{"key":"e_1_2_7_49_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.65.7.746"},{"key":"e_1_2_7_50_2","first-page":"91","article-title":"Reduced subgenual cingulate volumes in mood disorders: a meta\u2010analysis","volume":"33","author":"Hajek T","year":"2008","journal-title":"J Psychiatry Neurosci"},{"key":"e_1_2_7_51_2","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.152.3.341"},{"key":"e_1_2_7_52_2","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1176\/ajp.156.5.675","article-title":"Reciprocal limbic\u2010cortical function and negative mood: converging PET findings in depression and normal sadness","volume":"156","author":"Mayberg HS","year":"1999","journal-title":"Am J Psychiatry"},{"key":"e_1_2_7_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.05.019"},{"key":"e_1_2_7_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2009.05.022"},{"key":"e_1_2_7_55_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.22.13290"},{"key":"e_1_2_7_56_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.07m03745"},{"key":"e_1_2_7_57_2","doi-asserted-by":"publisher","DOI":"10.1089\/cap.2010.0094"},{"key":"e_1_2_7_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaac.2011.10.019"},{"key":"e_1_2_7_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2011.10.003"},{"key":"e_1_2_7_60_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2009.00678.x"},{"key":"e_1_2_7_61_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2009.00732.x"},{"key":"e_1_2_7_62_2","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0b013e328317f3cb"},{"key":"e_1_2_7_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2004.11.004"},{"key":"e_1_2_7_64_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-009-0077-2"},{"key":"e_1_2_7_65_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2005.00261.x"},{"key":"e_1_2_7_66_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2007.07071066"},{"key":"e_1_2_7_67_2","doi-asserted-by":"publisher","DOI":"10.1097\/CHI.0b013e3181900421"},{"key":"e_1_2_7_68_2","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.0786"},{"key":"e_1_2_7_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2009.10.003"}],"container-title":["Bipolar Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1399-5618.2012.01043.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1399-5618.2012.01043.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T00:48:11Z","timestamp":1698713291000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1399-5618.2012.01043.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9]]},"references-count":68,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["10.1111\/j.1399-5618.2012.01043.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1399-5618.2012.01043.x","archive":["Portico"],"relation":{},"ISSN":["1398-5647","1399-5618"],"issn-type":[{"value":"1398-5647","type":"print"},{"value":"1399-5618","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,9]]}}}