{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T03:10:02Z","timestamp":1761621002892},"reference-count":8,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,12,30]],"date-time":"2008-12-30T00:00:00Z","timestamp":1230595200000},"content-version":"vor","delay-in-days":10135,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[1981,4]]},"abstract":"<jats:p>Specific binding sites for opiate\u2010induced bradycardia, hypotension and EEG\u2010synchronization are located in areas bordering the IVth cerebral ventricle in the dog. To see if the clinically observed opiate\u2010induced respiratory depression is mediated selectively from ponto\u2010bulbar respiratory neurones, increasing concentrations of fentanyl (2.5\u20105\u201010\u201020 \u03bcg\/ml) were perfused through the IVth cerebral ventricle in canines. Contrary to the awake state, fentanyl\u2010perfusion during halothane\u2010anesthesia (0.75 vol %\/O<jats:sub>2<\/jats:sub>) induced a dose\u2010related increase in arterial P<jats:sc>co<\/jats:sc><jats:sub>2<\/jats:sub>. This effect was reversed by subsequent naloxone\u2010perfusion (20 \u03bcg\/ml). The administration of halothane alone over the same period of time did not affect P<jats:sc>co<\/jats:sc><jats:sub>2<\/jats:sub> in a similar manner. It is suggested that higher cortical centers which are involved in sensory awareness may modulate respiratory neurones in the medulla, since the depression of these higher centers by halothane resulted in opiate\u2010induced respiratory impairment. An additive effect of fentanyl\u2010 and halothane\u2010induced release of opiate\u2010like peptides (enkephalins) on respiration should also be considered.<\/jats:p>","DOI":"10.1111\/j.1399-6576.1981.tb01631.x","type":"journal-article","created":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T09:49:06Z","timestamp":1230803346000},"page":"171-173","source":"Crossref","is-referenced-by-count":36,"title":["Fentanyl in the Fourth Cerebral Ventricle Causes Respiratory Depression in the Anesthetized but Not in the Awake Dog"],"prefix":"10.1111","volume":"25","author":[{"given":"E.","family":"Freye","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Hartung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,12,30]]},"reference":[{"key":"e_1_2_1_2_1","unstructured":"Arndt J. O. Freye E.&Schenk G.(1980)Opiate receptors in the medulla and their possible importance for the control of wake\u2010fulness.Exp. Brain Res. (submitted for publication)."},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-196611000-00012"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-196105000-00004"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-197704000-00003"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00498453"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0160-5402(79)90023-8"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-196611000-00016"},{"key":"e_1_2_1_9_1","first-page":"259","article-title":"Die Atemdepression nach Fentanyl und ihre Antagonisierung mit Naloxone","volume":"27","author":"Schaer H.","year":"1978","journal-title":"Anaesthesist"}],"container-title":["Acta Anaesthesiologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1399-6576.1981.tb01631.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1399-6576.1981.tb01631.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,11]],"date-time":"2023-11-11T01:03:56Z","timestamp":1699664636000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1399-6576.1981.tb01631.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,4]]},"references-count":8,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1981,4]]}},"alternative-id":["10.1111\/j.1399-6576.1981.tb01631.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1399-6576.1981.tb01631.x","archive":["Portico"],"relation":{},"ISSN":["0001-5172","1399-6576"],"issn-type":[{"value":"0001-5172","type":"print"},{"value":"1399-6576","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,4]]}}}