{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T21:14:16Z","timestamp":1760217256665},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2008,12,30]],"date-time":"2008-12-30T00:00:00Z","timestamp":1230595200000},"content-version":"vor","delay-in-days":9891,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[1981,12]]},"abstract":"<jats:p>Midazolam, a new water\u2010soluble benzodiazepine, with an elimination half\u2010life of approximately 2 h, was compared with thiopentone for induction of general Anaesthesia in a randomized, single\u2010blind study. The patients were 60 healthy women undergoing legal abortion as outpatients. Midazolam provided smooth and reliable induction of Anaesthesia with few side\u2010effects. However, the induction time was considerably longer in the midazolam group (82.3 + 6.1) than in the thiopentone group (45.9 \u00b11.7 s). The dose of midazolam required for induction was 0.36\u00b10.01 mg\/kg, while that of thiopentone was 6.43 \u00b10.21 mg\/kg. Apnoea occurred with a frequency of 10 % in the midazolam group and 55 % in the thiopentone group, but was of equal duration in both groups. Circulatory conditions were more stable during induction with midazolam, with a slower fall in blood pressure and no change in heart rate. The patients were breathing O<jats:sub>2<\/jats:sub>\/N<jats:sub>2<\/jats:sub>O in proportions of 1:2.<\/jats:p><jats:p>To ensure adequate surgical anaesthesia, it was necessary to add halothane for short periods for all patients in the midazolam group and for 79% of the thiopentone group. Postoperatively, all patients who had received midazolam, but none induced with thiopentone, had anterograde amnesia; this lasted for more than 1 h. All patients in both groups could leave the hospital after routine postoperative observation for 3\u20134 h. Venous tolerance was good for both drugs.<\/jats:p>","DOI":"10.1111\/j.1399-6576.1981.tb01693.x","type":"journal-article","created":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T10:07:38Z","timestamp":1230804458000},"page":"492-496","source":"Crossref","is-referenced-by-count":15,"title":["Midazolam for Induction of Anaesthesia in Outpatients: A Comparison with Thiopentone"],"prefix":"10.1111","volume":"25","author":[{"given":"L.","family":"Berggren","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Eriksson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,12,30]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"852","article-title":"Benzodiazepine receptors","volume":"30","author":"Braestrup C.","year":"1980","journal-title":"Arzneimittel-Forsch. 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