{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T11:25:25Z","timestamp":1698060325165},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,12,30]],"date-time":"2008-12-30T00:00:00Z","timestamp":1230595200000},"content-version":"vor","delay-in-days":9039,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[1984,4]]},"abstract":"<jats:p>Delayed hypersensitivity to four common antigens was assessed in 32 patients undergoing major abdominal surgery randomly allocated to either general anaesthesia (fentanyl + O<jats:sub>2<\/jats:sub>\/N<jats:sub>2<\/jats:sub>O + postoperative pain relief with systemic opiates) or general anaesthesia + epidural analgesia (local anaesthetics + morphine) continued for 72 h. Skin\u2010test responses were performed 2 days before surgery and 1 day after surgery and compared to a similar retesting schedule in 16 comparable non\u2010operative control patients. Cumulated mean skin\u2010test responses increased from 1290 to 2330 mm<jats:sup>2<\/jats:sup> <jats:italic>(P&lt;0.0001)<\/jats:italic> during retesting in the non\u2010operative control group. In contrast, mean skin\u2010test responses in patients operated during general anaesthesia + systemic opiates for postoperative pain relief fell from 1422 to 1227 mm<jats:sup>2<\/jats:sup> (P=0.3) and in patients receiving epidural analgesia from 1228 to 890 mm<jats:sup>2<\/jats:sup> (P=0.06), without statistically significant differences between these two groups (Pg0.5). Thus, surgery leads to depression of delayed hypersensitivity and this impairment in immunofunction is not modified by an epidural analgesic regimen providing adequate pain relief.<\/jats:p>","DOI":"10.1111\/j.1399-6576.1984.tb02027.x","type":"journal-article","created":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T06:27:47Z","timestamp":1230791267000},"page":"128-131","source":"Crossref","is-referenced-by-count":10,"title":["Failure of Epidural Analgesia to Modify Postoperative Depression of Delayed Hypersensitivity"],"prefix":"10.1111","volume":"28","author":[{"given":"N.\u2010C.","family":"Hjorts\u00f8","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Andersen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Fr\u00f8sig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Neumann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Rogon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Kehlet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,12,30]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.1978.tb12415.x"},{"key":"e_1_2_1_3_2","first-page":"68","article-title":"Influence of anesthesia and surgery on immunocompetence","volume":"7","author":"Kehlet H.","year":"1982","journal-title":"Reg Anesth"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-197909000-00004"},{"key":"e_1_2_1_5_2","first-page":"38","article-title":"The modifying effect of general and regional anesthesia on the endocrine\u2010metabolic response to surgery","volume":"7","author":"Kehlet H.","year":"1982","journal-title":"Reg Anesth"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(80)90780-1"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.1982.tb01771.x"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197509042931013"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6109(16)41779-2"},{"key":"e_1_2_1_10_2","first-page":"363","article-title":"Irnmuno\u2010depression after major surgery in normal patients","volume":"78","author":"Slade MS","year":"1975","journal-title":"Surgery"},{"key":"e_1_2_1_11_2","unstructured":"Ryh\u00e4nenP..Effects of anesthesia and operative surgery on the immune response of patients of different ages. 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