{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T01:37:46Z","timestamp":1774661866142,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2008,12,30]],"date-time":"2008-12-30T00:00:00Z","timestamp":1230595200000},"content-version":"vor","delay-in-days":4230,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[1997,6]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold>Acid aspiration into one lung is known to cause both a local as well as remote organ injury characterized by neutrophil sequestration and subsequent edema. This study investigated the role of the complement cascade in the development of acid aspiration\u2010induced local lung and remote organ injuries using K\u201076 COONa (K76), an anticomplement agent that inhibits the complement pathway at the C5 step, and its usefulness as a treatment drug.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Anesthetized rats underwent tracheostomy and insertion of a cannula. K76 was intraperitoneally administrated prior to or immediately after the instillation of 0.1 ml of HC1 (0.1N) or phosphate buffer solution (PBS) into the left lung. Inflammatory responses were evaluated by tumor necrosis factor a (TNFa) in the plasma and the bronchoalveolar lavage fluid (BALF) (n=4), tissue myeloperoxidase (MPO), wet\u2010to\u2010dry weight ratio (W\/D ratio)(n=6), and protein concentration in the BALF (n=6).<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Acid instillation caused an increase in the plasma TNFa, which was significantly attenuated by the administration of K76 prior to or after the acid instillation. Acid instillation to the left lung resulted in an increase of MPO and W\/D ratios of the left lung, the right lung, and the small intestine. The administration of K76 inhibited the increase of MPO in these organs. K76 inhibited the increase of W\/D ratios of the right non\u2010in\u2010stillated lung and the small intestine. Acid instillation led to increased protein concentration in the BALF of the left lung, which was not inhibited by K76. K76 administrated after the acid instillation had the same effects. TNFa in the BALF was not detected in all groups.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold>These results suggest that localized acid aspiration induces, through the C5a step of the complement system\u2010dependent mechanisms, TNFa formation and neutrophil sequestration, which caused the increase of endothelial permeability of the systemic organs. K76 is effective as a treatment drug in modulating some of the injuries caused by the acid instillation, but further investigation is warranted as to its potential as a therapeutic agent.<\/jats:p>","DOI":"10.1111\/j.1399-6576.1997.tb04771.x","type":"journal-article","created":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T03:49:37Z","timestamp":1230781777000},"page":"713-718","source":"Crossref","is-referenced-by-count":13,"title":["Complement partially mediates acid aspiration\u2010induced remote organ injury in the rat"],"prefix":"10.1111","volume":"41","author":[{"given":"H.","family":"YAMADA","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"KUDOH","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"NISHIZAWA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"KANEKO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"MIYAZAKI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"OHARA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"OKUMURA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,12,30]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199502000-00023"},{"key":"e_1_2_1_3_2","first-page":"A761","article-title":"Effects of pentoxifylline administrated after HCl\u2010instillation into lung on TNF\u03b1 production and systemic injury in rabbits","volume":"151","author":"Kudoh I","year":"1995","journal-title":"Am J Respir Crit Care Med"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199010000-00013"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6060(05)80233-8"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.4049\/jimmunol.149.5.1744","article-title":"Role of complement in endotoxin\/ platelet\u2010activating factor induced lung injury","volume":"149","author":"Rabinovici R","year":"1992","journal-title":"J Immunol"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199611000-00021"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"2418","DOI":"10.4049\/jimmunol.122.6.2418","article-title":"An anticomplementary agent K\u201076 monocarboxylic acid: Its site and mechanism of the complement activation cascade","volume":"122","author":"Hong K","year":"1979","journal-title":"J Immunol"},{"key":"e_1_2_1_9_2","first-page":"483","article-title":"Effects of anticomplementary reagents, K\u201076 and FUT175, on xenograft survival","volume":"24","author":"Miyagawa S","year":"1992","journal-title":"Transplantation Proc"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1159\/000467829"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1348-0421.1980.tb02914.x"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(84)90147-9"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(84)90202-6"},{"key":"e_1_2_1_14_2","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent. 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