{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T16:32:20Z","timestamp":1748017940040},"reference-count":0,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2008,12,30]],"date-time":"2008-12-30T00:00:00Z","timestamp":1230595200000},"content-version":"vor","delay-in-days":4230,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[1997,6]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold>Malignant hyperthermia susceptibility is a pharmacogenetic disorder in which susceptible individuals may develop a potentially life\u2010threatening hypermetabolism when exposed to certain anaesthetic agents. The most common diagnostic method is the <jats:italic>in vitro<\/jats:italic> contracture test (IVCT) of skeletal muscle biopsies. There is a wide variation in the size of contractures between susceptible individuals and the reproducibility of the test in humans has not been evaluated.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> We have performed the IVCT in 4 monozygote pairs of twins, which gave us on opportunity to study the reproducibility. Results: The clinical diagnoses were consistent in all twin pairs, although slight differences in contractures and thresholds were seen.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> In this material the reproducibility of the IVCT was found to be satisfactory.<\/jats:p>","DOI":"10.1111\/j.1399-6576.1997.tb04774.x","type":"journal-article","created":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T03:49:29Z","timestamp":1230781769000},"page":"731-735","source":"Crossref","is-referenced-by-count":4,"title":["Results of in vitro contracture tests for the diagnosis of malignant hyperthermia susceptibility in monozygote twins"],"prefix":"10.1111","volume":"41","author":[{"given":"G.","family":"ISLANDER","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. RANKLEV","family":"TWETMAN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,12,30]]},"container-title":["Acta Anaesthesiologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1399-6576.1997.tb04774.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1399-6576.1997.tb04774.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1399-6576.1997.tb04774.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T10:18:24Z","timestamp":1694686704000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1399-6576.1997.tb04774.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,6]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1997,6]]}},"alternative-id":["10.1111\/j.1399-6576.1997.tb04774.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1399-6576.1997.tb04774.x","archive":["Portico"],"relation":{},"ISSN":["0001-5172","1399-6576"],"issn-type":[{"value":"0001-5172","type":"print"},{"value":"1399-6576","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,6]]}}}