{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T15:29:22Z","timestamp":1758814162769},"reference-count":15,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2004,9,7]],"date-time":"2004-09-07T00:00:00Z","timestamp":1094515200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2004,10]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> Adjunctive use of nonsteroidal anti\u2010inflammatory drugs has become increasingly popular in the perioperative period because of their opioid\u2010sparing effects. This randomized, controlled, double\u2010dummy study was designed to evaluate the cost\u2010effectiveness of using oral rofecoxib as an alternative to intravenous ketoprofen for pain management in patients undergoing urologic surgery.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Seventy patients were randomly assigned to receive either a placebo (Control) or rofecoxib 50\u2003mg po (Rofecoxib) 1\u2003h prior to surgery. After a standardized spinal anesthetic, patients in the Control group received ketoprofen 100\u2003mg IV q 8\u2003h for 24\u2003h, while the Rofecoxib group received an equivolume of saline at 8\u2010h intervals for 24\u2003h. Both groups were allowed to self\u2010administer morphine (1\u2003mg IV boluses) using a PCA delivery system. The need for \u2018rescue\u2019 analgesic medication, as well as pain scores [using an 11\u2010point verbal rating scale (VRS) (0\u2003=\u2003none to 10\u2010severe)], were recorded at 1, 2, 6, 12, and 24\u2010h intervals after surgery. In addition, the incidences of side\u2010effects were recorded at the end of the study period.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Total amount of morphine required in the initial 24\u2010h postoperative period was nonsignificantly reduced in the Rofecoxib group (29\u2003\u00b1\u20032 vs. 37\u2003\u00b1\u20034\u2003mg). More importantly, the percentage of patients reporting moderate\u2010to\u2010severe pain (VRS score \u22654) during the study period was lower in the Rofecoxib group (12 vs. 22%, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05). The daily cost of rofecoxib (USD 1.14 for 50\u2010mg dose) was also significantly less than ketoprofen (USD 3.06 for three 100\u2010mg doses).<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Premedication with oral rofecoxib (50\u2003mg) is a cost\u2010effective alternative to the parenteral nonselective NSAID, ketoprofen (100\u2003mg q 8\u2003h), when used as an adjuvant to PCA morphine for pain management after urologic surgery.<\/jats:p>","DOI":"10.1111\/j.1399-6576.2004.00496.x","type":"journal-article","created":{"date-parts":[[2004,9,7]],"date-time":"2004-09-07T12:00:07Z","timestamp":1094558407000},"page":"1190-1193","source":"Crossref","is-referenced-by-count":8,"title":["Efficacy of oral rofecoxib versus intravenous ketoprofen as an adjuvant to PCA morphine after urologic surgery"],"prefix":"10.1111","volume":"48","author":[{"given":"M. C.","family":"Cabrera","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Schmied","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Derderian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. F.","family":"White","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Vega","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Santelices","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Verdugo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,9,7]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-199412000-00025"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-200301000-00015"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200210000-00027"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-200201000-00010"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000085637.00864.D7"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000111110.94186.55"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/88.1.72"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.1998.tb05083.x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-200203000-00019"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2253-4-3"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000069507.93582.6E"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.18.2411"},{"key":"e_1_2_6_14_2","first-page":"429","article-title":"Peri\u2010operative blood loss and non\u2010steroidal anti\u2010inflammatory drugs: An investigation using diclofenac in patients undergoing transurethral resection of the prostate","volume":"4","author":"Bricker SR","year":"1987","journal-title":"Eur J Anesth"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeh107"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-8180(01)00219-7"}],"container-title":["Acta Anaesthesiologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1399-6576.2004.00496.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1399-6576.2004.00496.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T12:49:58Z","timestamp":1697201398000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1399-6576.2004.00496.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,9,7]]},"references-count":15,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2004,10]]}},"alternative-id":["10.1111\/j.1399-6576.2004.00496.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1399-6576.2004.00496.x","archive":["Portico"],"relation":{},"ISSN":["0001-5172","1399-6576"],"issn-type":[{"value":"0001-5172","type":"print"},{"value":"1399-6576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,9,7]]}}}