{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T15:44:12Z","timestamp":1697211852583},"reference-count":18,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2004,10,25]],"date-time":"2004-10-25T00:00:00Z","timestamp":1098662400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2004,11]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> The aim of this study was to evaluate the effect of ephedrine administered prior to induction of anaesthesia on the onset time of succinylcholine for endotracheal intubation.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Patients were randomly assigned to receive intravenously (i.v.) either 70\u2003\u00b5g\u2003kg<jats:sup>\u22121<\/jats:sup> of ephedrine (Group I; n\u2003=\u200325) or saline (Group II; n\u2003=\u200325) 3\u2003min before induction of anaesthesia. Induction of anaesthesia was provided with propofol 2\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup> plus remifentanil 1\u2003\u00b5g\u2003kg<jats:sup>\u22121<\/jats:sup>. Onset time and duration of muscle fasciculation and onset time of succinylcholine were recorded. Intubation was attempted after establishment of 100% thumb relaxation and difficulties were recorded. Heart rate, pulse oxymetry (SpO<jats:sub>2<\/jats:sub>) and mean arterial pressure (MAP) were also recorded.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> The onset time of succinylcholine were significantly (<jats:italic>P\u2003&lt;\u2003<\/jats:italic>0.001) shorter in Group I (26\u2003\u00b1\u20034\u2003s), when compared with Group II (43\u2003\u00b1\u20036\u2003s). Patients in Group I were intubated at 49\u2003\u00b1\u20037\u2003s compared with 68\u2003\u00b1\u200310\u2003s in Group II. The score of intubation was similar in both groups. Duration of muscle fasciculation was longer in Group II. Heart rate and MAP increased significantly (<jats:italic>P\u2003&lt;\u2003<\/jats:italic>0.05) after ephedrine injection, compared with the baseline value in Group I.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> The onset time of succinylcholine can be shortened with ephedrine pretreatment.<\/jats:p>","DOI":"10.1111\/j.1399-6576.2004.00529.x","type":"journal-article","created":{"date-parts":[[2004,10,25]],"date-time":"2004-10-25T13:38:51Z","timestamp":1098711531000},"page":"1306-1309","source":"Crossref","is-referenced-by-count":7,"title":["Effect of ephedrine on the onset time of succinylcholine"],"prefix":"10.1111","volume":"48","author":[{"given":"S.","family":"Ganidagli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Cengiz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"Baysal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,25]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2044.1998.00342.x"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2044.2001.01962.x"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-199708000-00034"},{"key":"e_1_2_5_5_2","first-page":"111","article-title":"Rocuronium with alfentanil and propofol allows intubation within 45 seconds","volume":"11","author":"Crul JF","year":"1995","journal-title":"Eur J Anaesthesiol Suppl"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-200005001-00006"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-200005000-00041"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000034551.93647.3A"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/81.4.540"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03026928"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.16.2.174"},{"key":"e_1_2_5_12_2","first-page":"34","article-title":"[Vascular effect of ephedrine in muscular and mesenteric regions]","volume":"185","author":"Wepierre J","year":"1970","journal-title":"Arch Int Pharmacodyn Ther"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-6576.2003.00218.x"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.1996.tb07799.x"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-198601000-00011"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199402000-00011"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2004.00378.x"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1467-2995.2002.00095.x"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.0003-2409.2001.02449.x"}],"container-title":["Acta Anaesthesiologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1399-6576.2004.00529.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1399-6576.2004.00529.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T15:20:09Z","timestamp":1697210409000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1399-6576.2004.00529.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,10,25]]},"references-count":18,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2004,11]]}},"alternative-id":["10.1111\/j.1399-6576.2004.00529.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1399-6576.2004.00529.x","archive":["Portico"],"relation":{},"ISSN":["0001-5172","1399-6576"],"issn-type":[{"value":"0001-5172","type":"print"},{"value":"1399-6576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,10,25]]}}}