{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T04:33:52Z","timestamp":1791088432634,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,3,17]],"date-time":"2005-03-17T00:00:00Z","timestamp":1111017600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2005,4]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> Xenon in low concentrations has been investigated in neuroradiology to measure cerebral blood flow (CBF). Several reports have suggested that inhalation of Xenon might increase intracranial pressure (ICP) by increasing the cerebral blood flow and blood volume, raising concerns about using Xenon as an anesthetic in higher concentrations for head\u2010injured patients.<\/jats:p><jats:p>A porcine study is presented in which the effects of inhaled 75% Xenon on elevated ICP, cerebral perfusion pressure and the efficacy of hyperventilation for ICP treatment were compared with nitrous oxide anesthesia and total intravenous anesthesia (TIVA).<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Twenty\u2010one pentobarbital\u2010anesthetized pigs (age: 12\u201316\u2003weeks) were randomly assigned to three groups to receive either 4\u2003h of Xenon\u2010oxygen ventilation, nitrous oxide\u2010oxygen ventilation or air\u2010oxygen (75%\/25%) ventilation, respectively. After instrumentation for parenchymal ICP measurement and ICP manipulation, an epidurally placed 6\u2010F balloon catheter was inflated until a target ICP of 20\u2003mmHg was achieved.<\/jats:p><jats:p>After 4\u2003h of anesthesia hyper\u2010 and hypoventilation maneuvers were performed and consecutive ICP and CBF changes were investigated.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Intracranial pressure and CBF increased significantly in the nitrous oxide group as compared with the controls. There was no increase of ICP or CBF in the Xenon or control group. Intracranial pressure changed in all three groups corresponding to hyper\u2010 and hypoventilation.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> During Xenon anesthesia, elevated ICP is not increased further and is partially reversible by hyperventilation. Our study suggests that inhalation of 75% Xenon seems not to be contraindicated in patients with elevated ICP.<\/jats:p>","DOI":"10.1111\/j.1399-6576.2005.00609.x","type":"journal-article","created":{"date-parts":[[2005,3,17]],"date-time":"2005-03-17T21:43:18Z","timestamp":1111095798000},"page":"494-501","source":"Crossref","is-referenced-by-count":10,"title":["Effect of Xenon on elevated intracranial pressure as compared with nitrous oxide and total intravenous anesthesia in 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