{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T09:07:25Z","timestamp":1785575245185,"version":"3.56.0"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,2,8]],"date-time":"2005-02-08T00:00:00Z","timestamp":1107820800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2005,3]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> Hydroxyethyl starch (HES) solutions impair haemostatic mechanisms. The impact of the degree of substitution (DS) of a HES solution on thromboelastometry tracings is unclear. Therefore we tested the hypothesis of whether the DS has an effect on the haemostatic defect caused by HES, and assessed whole blood coagulation by thromboelastometry coagulation analysis (ROTEM<jats:sup>\u00ae<\/jats:sup>, Pentapharm Co., Munich, Germany) in serial <jats:italic>in vitro<\/jats:italic> haemodilutions of colloids.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Whole blood was withdrawn from 12 volunteers in a crossover study. Six per cent low\u2010molecular weight HES with a high (HES MW 120\u2003kDa\/degree of substitution 0.7) and low (HES MW 130\u2003kDa\/0.4) degree of substitution, 4% succinylated gelatin (GEL) or 4% albumin (ALB) was added to citrated venous whole blood samples to make 20, 40, 60 vol.% end\u2010concentrations of each of the solutions. Samples were analyzed by ROTEM<jats:sup>\u00ae<\/jats:sup>.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> There was a comparable decrease in maximum clot firmness (MCF) and shear elastic modulus [<jats:italic>G\u2003=\u2003<\/jats:italic>5000\u2003\u00d7\u2003MCF\/(100\u2013MCF)] by HES 120\/0.7 and HES 130\/0.4 at 20 and 40 vol.% dilutions. At 60 vol.% dilution HES 120\/0.7 decreased less alpha\u2010angle and MCF than HES 130\/0.4 (<jats:italic>P\u2003&lt;\u2003<\/jats:italic>0.05). With moderate dilutions all colloids shortened coagulation time (CT). At 20, 40 and 60 vol.% dilutions MCF and G were more decreased in both HES groups than in the ALB and GEL groups (<jats:italic>P\u2003&lt;\u2003<\/jats:italic>0.05). Furthermore, at 40 and 60 vol.% dilutions G deteriorated more in the GEL than in the ALB group (<jats:italic>P\u2003&lt;\u2003<\/jats:italic>0.05).<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold>  <jats:italic>In vitro<\/jats:italic> the impact of the degree of substitution of HES solution on thromboelastometry coagulation analysis was modest. Haemodilution with gelatin and albumin induced fewer coagulation abnormalities than HES. In addition, the haemodilution with gelatin impaired coagulation more than albumin solution.<\/jats:p>","DOI":"10.1111\/j.1399-6576.2005.00619.x","type":"journal-article","created":{"date-parts":[[2005,3,7]],"date-time":"2005-03-07T09:47:17Z","timestamp":1110188837000},"page":"373-378","source":"Crossref","is-referenced-by-count":74,"title":["Artificial colloids impair haemostasis. An <i>in vitro<\/i> study using thromboelastometry coagulation analysis"],"prefix":"10.1111","volume":"49","author":[{"given":"T. T.","family":"Niemi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. H.","family":"Kuitunen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,2,8]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.1998.tb05385.x"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000096006.60716.F6"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-199376060-00002"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(01)02745-X"},{"key":"e_1_2_6_6_2","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1055\/s-0038-1649964","article-title":"HES 200\/0.5 is not HES 200\/0.5. 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