{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T22:02:01Z","timestamp":1789768921178,"version":"4.0.1"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,3,17]],"date-time":"2005-03-17T00:00:00Z","timestamp":1111017600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2005,4]]},"abstract":"<jats:p><jats:bold>Background:\u2003<\/jats:bold> In recent years it has become increasingly clear that a cross\u2010talk between the inflammatory response and blood coagulation exists, although many of the underlying mechanisms remain unclear. In the present study we investigated the potential anti\u2010inflammatory properties of two different anticoagulant compounds, i.e. active\u2010site inactivated FVIIa (FVIIai) and fondaparinux sodium, a selective FXa inhibitor, administered as pretreatment in a model of intestinal I\/R in rats.<\/jats:p><jats:p><jats:bold>Methods:\u2003<\/jats:bold> Endothelial barrier permeability was assessed using the vascular leakage of radiolabelled human serum albumin, tissue neutrophil sequestration was quantitated by myeloperoxidase (MPO) activity, and plasma levels of macrophage inflammatory protein (MIP)\u20102 were examined using an enzyme\u2010linked\u2010immuno\u2010sorbent assay after 40\u2003min of intestinal ischaemia and 6\u2003h of reperfusion in the rat (n\u2003=\u200334). Pretreatment with FVIIai or fondaparinux sodium was administered 90\u2003min before initiation of ischaemia.<\/jats:p><jats:p><jats:bold>Results:\u2003<\/jats:bold> Endothelial\u2010barrier permeability in all examined organs, myeloperoxidase activity in the lungs, and ileum and MIP\u20102 levels in plasma increased after intestinal I\/R. Pretreatment with FVIIai decreased the endothelial barrier permeability and MPO activity in the ileum, and a tendency towards decreased permeability was also observed in the lungs. Fondaparinux did not affect the endothelial barrier permeability or MPO activity. Both FVIIai and fondaparinux decreased the MIP\u20102 levels in plasma after intestinal I\/R.<\/jats:p><jats:p><jats:bold>Conclusions:\u2003<\/jats:bold> Inhibition of the TF\u2010FVIIa complex by FVIIai can attenuate inflammatory responses in connection with intestinal I\/R\u2010injury and could represent a potentially important therapeutic strategy for the prevention of organ dysfunction. Potential anti\u2010inflammatory properties of fondaparinux and other inhibitors of FXa are not excluded and need further investigation.<\/jats:p>","DOI":"10.1111\/j.1399-6576.2005.00633.x","type":"journal-article","created":{"date-parts":[[2005,3,17]],"date-time":"2005-03-17T21:43:18Z","timestamp":1111095798000},"page":"517-524","source":"Crossref","is-referenced-by-count":14,"title":["Effects of anticoagulant treatment on intestinal ischaemia and reperfusion injury in 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