{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T10:24:03Z","timestamp":1768472643727,"version":"3.49.0"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,3,17]],"date-time":"2005-03-17T00:00:00Z","timestamp":1111017600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2005,4]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> \u2002The effect of alfentanil on intracranial pressure (ICP) in patients with supratentorial cerebral tumors has only been sparsely examined and with somewhat contradictory results.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Thirty\u2010one patients were anesthetized with propofol and fentanyl. After removal of the bone flap a bolus\u2010dose of alfentanil 10 (group 1), 20 (group 2), or 30\u2003\u00b5g\u2003kg<jats:sup>\u22121<\/jats:sup> (group 3) was administered followed by an infusion of 10, 20, or 30\u2003\u00b5g\u00b7kg<jats:sup>\u22121<\/jats:sup>\u00b7h<jats:sup>\u22121<\/jats:sup> to patients in groups 1, 2, and 3, respectively. A control group received no alfentanil. Subdural ICP, mean arterial blood pressure (MAP), and cerebral perfusion pressure (CPP) were monitored and arterial and jugular bulb blood were sampled before and every minute for 5\u2003min after the bolus administration of alfentanil and again after 5\u2003min of hyperventilation to be able to calculate cerebral arterio\u2010venous oxygen content difference (AVDO<jats:sub>2<\/jats:sub>) and carbon dioxide reactivity (CO<jats:sub>2<\/jats:sub>\u2010reactivity).<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> No changes in subdural ICP or AVDO<jats:sub>2<\/jats:sub> from alfentanil in the study period were observed within the groups. However, alfentanil decreased MAP and CPP. The maximum CPP decrease (mean value of each group) was 4\u2003mmHg, 8\u2003mmHg, and 18\u2003mmHg in groups 1, 2, and 3, respectively. There was no difference between groups as regards the CO<jats:sub>2<\/jats:sub>\u2010reactivity.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> We conclude that administration of alfentanil to propofol\u2010fentanyl anesthetized patients with supratentorial cerebral tumors decreases MAP and CPP in a dose\u2010related way, but does not influence subdural ICP, AVDO<jats:sub>2<\/jats:sub> or the CO<jats:sub>2<\/jats:sub>\u2010reactivity.<\/jats:p>","DOI":"10.1111\/j.1399-6576.2005.00648.x","type":"journal-article","created":{"date-parts":[[2005,3,17]],"date-time":"2005-03-17T21:43:18Z","timestamp":1111095798000},"page":"445-452","source":"Crossref","is-referenced-by-count":6,"title":["Effect of alfentanil on intracranial pressure during propofol\u2013fentanyl anesthesia for craniotomy.\u2003A randomized prospective dose\u2013response study"],"prefix":"10.1111","volume":"49","author":[{"given":"K. S.","family":"Olsen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Juul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. E.","family":"Cold","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,3,17]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-199608000-00025"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-199010000-00018"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199302000-00012"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1080\/02688699650040548"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199902000-00050"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-199603000-00030"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199201000-00011"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/72.1.66"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1977.46.3.0271"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199011000-00017"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00008506-200001000-00004"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-199103000-00013"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1080\/02688699943231"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1080\/026886900408414"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.2004.03604.x"},{"key":"e_1_2_5_17_2","first-page":"276","article-title":"Subdural monitoring of ICP during craniotomy: Thresholds of cerebral swelling\/herniation","volume":"71","author":"Bundgaard H","year":"1998","journal-title":"Acta Neurochir Suppl"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001010050170"}],"container-title":["Acta Anaesthesiologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1399-6576.2005.00648.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1399-6576.2005.00648.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T21:20:17Z","timestamp":1696886417000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1399-6576.2005.00648.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,3,17]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2005,4]]}},"alternative-id":["10.1111\/j.1399-6576.2005.00648.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1399-6576.2005.00648.x","archive":["Portico"],"relation":{},"ISSN":["0001-5172","1399-6576"],"issn-type":[{"value":"0001-5172","type":"print"},{"value":"1399-6576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,3,17]]}}}