{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:55:43Z","timestamp":1768265743345,"version":"3.49.0"},"reference-count":17,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2005,4,21]],"date-time":"2005-04-21T00:00:00Z","timestamp":1114041600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2005,8]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> Hypotensive anaesthesia (HA) and acute normovolaemic haemodilution (ANH) are used separately to decrease per\u2010operative blood loss. Reducing blood viscosity by adding ANH to HA may appear profitable in a situation with lowered perfusion pressure and concern about organ ischemia. The aim of this study was to clarify the influence of HA in combination with ANH using crystalloid or colloid as replacement fluid on renal function.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Hypotensive anaesthesia was induced in 11 patients referred to major spine surgery using sevoflurane in combination with fentanyl\/remifentanil. Acute normovolaemic haemodilution was carried out by drawing venous blood into standard blood bags and replacing it by isotonic saline 0.9% (Group S) or HES 130\/0.4 (Group V). Renal function was evaluated before, during and up to 8\u2003h after hypotension as the glomerular filtration rate (GFR) and effective renal plasma flow (ERPF) by means of <jats:sup>51<\/jats:sup>Cr\u2010EDTA and <jats:sup>125<\/jats:sup>I\u2010Hippuran clearances.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Lowering mean arterial blood pressure decreased GFR and ERPF in both groups. During hypotension ERPF was lower in Group S (n\u2003=\u20035) than Group V (n\u2003=\u20036). Renal function was normalized postoperatively. We found a positive but non\u2010significant correlation between the relative GFR change and the duration of hypotension.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> In conclusion, our study demonstrated that renal function, assessed by GFR and ERPF, is transiently reduced during the combination of hypotensive anaesthesia and acute normovolaemic haemodilution. A colloid\u2010based fluid regime (HES 130\/0.4) used for haemodilution may preserve renal function to a greater extent than a crystalloid\u2010based regime (0.9% saline).<\/jats:p>","DOI":"10.1111\/j.1399-6576.2005.00714.x","type":"journal-article","created":{"date-parts":[[2005,7,26]],"date-time":"2005-07-26T18:54:33Z","timestamp":1122404073000},"page":"969-974","source":"Crossref","is-referenced-by-count":30,"title":["Renal effects of hypotensive anaesthesia in combination with acute normovolaemic haemodilution with hydroxyethyl starch 130\/0.4 or isotonic saline"],"prefix":"10.1111","volume":"49","author":[{"given":"C.","family":"Fenger\u2010Eriksen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Hartig Rasmussen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Kappel Jensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Anker\u2010M\u00f8ller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Heslop","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Fr\u00f8ki\u00e6r","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"T\u00f8nnesen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,4,21]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"580","article-title":"The effect of two levels of hypotension on intraoperative blood loss during total hip arthroplasty performed under lumbar epidural anesthesia","volume":"76","author":"Reference List. 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