{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T12:54:23Z","timestamp":1773665663096,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2005,4,21]],"date-time":"2005-04-21T00:00:00Z","timestamp":1114041600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2005,9]]},"abstract":"<jats:p>Colloid\u2010mediated hypocoagulability is clinically important, but the mechanisms responsible for coagulopathy have been incompletely defined. Thus, my goal was to elucidate how colloids decrease plasma coagulation function. Plasma was diluted 0% or 40% with 0.9% NaCl, three different hydroxyethyl starches (HES, mean molecular weight 450, 220 or 130\u2003kDa), or 5% human albumin. Samples (n\u2003=\u20036 per condition) were activated with celite, and diluted samples had either no additions or addition of fibrinogen (FI), thrombin (FIIa) or activated Factor XIII (FXIIIa) to restore protein function to prediluted values. Thrombelastographic variables measured included clot propagation (angle, \u03b1), and clot strength (amplitude, A; or shear elastic modulus, G). Dilution with 0.9% NaCl significantly decreased \u03b1, A and <jats:italic>G<\/jats:italic>\u2010values compared to undiluted samples. Supplementation with FI, but not FIIa or FXIIIa, resulted in 0.9% NaCl\u2010diluted thrombelastographic variable values not different from those of undiluted samples. FI supplementation of HES 450, HES 220, HES 130 and albumin\u2010diluted samples only partially restored \u03b1, A and <jats:italic>G<\/jats:italic>\u2010values compared to undiluted samples. FIIa addition only improved clot propagation and strength in albumin\u2010diluted samples. FXIIIa supplementation improved propagation in samples diluted with HES 450, HES 220 and albumin, and clot strength improved in HES 450 and albumin\u2010diluted plasma. Considered as a whole, these data support compromise of FIIa\u2010FI and FXIIIa \u2013 fibrin polymer interactions as the mechanisms by which colloids compromise plasma coagulation. Investigation to determine if clinical enhancement of FXIII activity and\/or FI concentration (e.g. fresh\u2010frozen plasma, cryoprecipitate) can attenuate colloid\u2010mediated decreases in hemostasis is warranted.<\/jats:p>","DOI":"10.1111\/j.1399-6576.2005.00733.x","type":"journal-article","created":{"date-parts":[[2005,8,11]],"date-time":"2005-08-11T16:29:02Z","timestamp":1123777742000},"page":"1163-1171","source":"Crossref","is-referenced-by-count":100,"title":["Colloids decrease clot propagation and strength: role of factor XIII\u2010fibrin polymer and thrombin\u2013fibrinogen interactions"],"prefix":"10.1111","volume":"49","author":[{"given":"V. 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