{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T14:23:02Z","timestamp":1785507782153,"version":"3.56.0"},"reference-count":21,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2005,8,15]],"date-time":"2005-08-15T00:00:00Z","timestamp":1124064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2005,10]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> In this study, we investigated the inhibitory effects of desflurane and sevoflurane on oxytocin\u2010induced contractions of isolated human myometrium.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Following delivery of the infant and placenta, a small segment of myometrium was excised from the upper incisional surface of the lower uterine segment and 20 strips, randomly assigned into two groups (<jats:italic>n<\/jats:italic>\u2003=\u200310), were obtained from 20 non\u2010laboring term parturients. The study protocol consisted of a 60\u2010min period of spontaneous contractions, control recording with oxytocin 2\u2003\u00d7\u200310<jats:sup>9<\/jats:sup>\u2003<jats:sc>m<\/jats:sc> (10\u2010min period), washout interval of 10\u2003min, volatile administration (three times per 15\u2010min period) of 0.5, 1 and 2 minimum alveolar concentration (MAC), response to oxytocin (10\u2010min period), a further washout interval (10\u2010min period) and subsequent control recording with oxytocin without anesthetics.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> After oxytocin administration, the frequency and amplitude of contractions increased (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05) and the duration decreased (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05). The frequency and amplitude of contractions induced with oxytocin decreased significantly at 0.5, 1 and 2 MAC of desflurane and sevoflurane (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05). The amplitude of contractions was significantly different at 1 MAC between the two groups (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05). The duration of contractions at 2 MAC decreased in both groups (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05).<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Desflurane and sevoflurane at 0.5, 1 and 2 MAC inhibit the frequency and amplitude of myometrial contractions induced with oxytocin in a dose\u2010dependent manner. However, desflurane inhibits the amplitude less than sevoflurane at 1 MAC. We suggest that 0.5 MAC of both agents and 1 MAC of desflurane may be safely used in the presence of oxytocin following delivery of the infant and placenta during Cesarean section without fear of uterine atony and hemorrhage.<\/jats:p>","DOI":"10.1111\/j.1399-6576.2005.00804.x","type":"journal-article","created":{"date-parts":[[2005,9,2]],"date-time":"2005-09-02T16:48:53Z","timestamp":1125679733000},"page":"1355-1359","source":"Crossref","is-referenced-by-count":43,"title":["Inhibitory effects of desflurane and sevoflurane on oxytocin\u2010induced contractions of isolated pregnant human myometrium"],"prefix":"10.1111","volume":"49","author":[{"given":"K.","family":"Yildiz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Dogru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Dalgic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. 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