{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T09:56:59Z","timestamp":1760608619364},"reference-count":23,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2005,10,13]],"date-time":"2005-10-13T00:00:00Z","timestamp":1129161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2005,11]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> It is common today to use tumescent anaesthesia with large doses of lidocaine for liposuction. The purpose of the present study was to evaluate lidocaine plasma levels and objective and subjective symptoms during 20\u2003h after tumescent anaesthesia with approximately 35\u2003mg per kg bodyweight of lidocaine for abdominal liposuction.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Three litres of buffered solution of 0.08% lidocaine with epinephrine was infiltrated subcutaneously over the abdomen in eight female patients during monitored intravenous (i.v.) light sedation. Plasma levels of lidocaine and signs of subjective and objective symptoms were recorded every 3\u2003h for 20\u2003h after liposuction.<\/jats:p><jats:p><jats:bold>Results:\u2003<\/jats:bold> Lidocaine 33.2\u2003\u00b1\u20031.8\u2003mg\/kg was given at a rate of 116\u2003\u00b1\u200311\u2003ml\/min. Peak plasma levels (2.3\u2003\u00b1\u20030.63\u2003\u00b5g\/ml) of lidocaine occurred after 5\u201317\u2003h. No correlation was found between peak levels and dose per kg bodyweight or total amount of lidocaine infiltrated. One patient experienced tinnitus after 14\u2003h when a plasma level of 3.3\u2003\u00b5g\/ml was recorded.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Doses of lidocaine up to 35\u2003mg\/kg were sufficient for abdominal liposuction using the tumescent technique and gave no fluid overload or toxic symptoms in eight patients, but with this dose there is still a risk of subjective symptoms in association with the peak level of lidocaine that may appear after discharge.<\/jats:p>","DOI":"10.1111\/j.1399-6576.2005.00885.x","type":"journal-article","created":{"date-parts":[[2010,8,12]],"date-time":"2010-08-12T14:58:42Z","timestamp":1281625122000},"page":"1487-1490","source":"Crossref","is-referenced-by-count":43,"title":["Plasma lidocaine levels and risks after liposuction with tumescent anaesthesia"],"prefix":"10.1111","volume":"49","author":[{"given":"H.","family":"Nordstr\u00f6m","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"St\u00e5nge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,10,13]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/074880688700400403"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-199903000-00036"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.1990.tb03961.x"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.117045"},{"key":"e_1_2_7_6_2","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S0094-1298(20)32615-8","article-title":"Wetting solutions in ultrasound\u2010assisted lipoplasty","volume":"26","author":"Fodor PB","year":"1999","journal-title":"Clin Plast Surg"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-199405000-00017"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-199606000-00009"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.1996.tb00634.x"},{"key":"e_1_2_7_10_2","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/S0094-1298(20)32560-8","article-title":"Tumescent liposuction. 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