{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T19:39:34Z","timestamp":1773430774836,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,11,15]],"date-time":"2005-11-15T00:00:00Z","timestamp":1132012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2006,2]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> Although the contribution of the \u03b3\u2010aminobutyric acid (GABA) receptor system in peripheral chemosensation is unclear, immunohistochemistry has demonstrated the presence of GABA\u2010ergic receptors in mammalian carotid bodies. We hypothesized that an activation of the carotid body GABA receptors would counteract the depolarizing effect of hypoxia.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> The carotid body with arterial supply and the carotid sinus nerve was removed en bloc from New Zealand White rabbits and placed in a perfusion chamber. The carotid body preparation was perfused via the cut common carotid artery with a modified Tyrode's solution at a rate of 3.5\u20134.5\u2003ml\/min with a constant pressure of 45\u2003cmH<jats:sub>2<\/jats:sub>O. The carotid sinus nerve firing frequency (Hz) was recorded at two different oxygen tension levels during perfusion with midazolam of 1, 10 and 100\u2003\u00b5g\/l.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> The frequency was decreased by midazolam in a dose\u2010dependent manner (<jats:italic>n<\/jats:italic>\u2003=\u20038). Firing frequencies (mean\u2003\u00b1\u2003SEM) at the low oxygen tension level decreased from 643.13\u2003\u00b1\u200367.2\u2003Hz in the control to 554.5\u2003\u00b1\u200367.7\u2003Hz (<jats:italic>P\u2003=<\/jats:italic>\u20030.054 vs. control), 509.01\u2003\u00b1\u2003100.5\u2003Hz (<jats:italic>P\u2003&lt;<\/jats:italic>\u20030.012 vs. control) and 422.6\u2003\u00b1\u200377.3\u2003Hz (<jats:italic>P\u2003&lt;<\/jats:italic>\u20030.001 vs. control) during perfusion with midazolam of 1, 10 and 100\u2003\u00b5g\/l, respectively.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Midazolam depresses carotid body chemoreceptor activity in a dose\u2010dependent manner.<\/jats:p>","DOI":"10.1111\/j.1399-6576.2005.00896.x","type":"journal-article","created":{"date-parts":[[2005,11,15]],"date-time":"2005-11-15T15:17:33Z","timestamp":1132067853000},"page":"144-149","source":"Crossref","is-referenced-by-count":16,"title":["Midazolam depresses carotid body chemoreceptor activity"],"prefix":"10.1111","volume":"50","author":[{"given":"C.","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Shvarev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Takeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Sakamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. G. E.","family":"Lindahl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. 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