{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T18:15:12Z","timestamp":1761675312389},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,1,18]],"date-time":"2006-01-18T00:00:00Z","timestamp":1137542400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2006,2]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> Metohexital and propofol are short\u2010acting induction agents, which have a tendency to prolong the QTc interval of the ECG. We studied whether this increase could be prevented by combining a beta\u2010blocking agent, esmolol, with these drugs. Simultaneously, we studied the hemodynamic effects of these combinations.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> In a randomized, double\u2010blind study, 80 ASA I\u2013II young adults were premedicated with oxycodone and atropin and allocated to one of four groups: propofol (P), propofol\u2003+\u2003esmolol (P +\u2003E), metohexital (E) or metohexital\u2003+\u2003esmolol (M\u2003+\u2003E). The doses were 2\u2003mg\/kg propofol\/metohexital and 1\u2003mg\/kg esmolol. Alfentanil 15\u2003\u00b5g\/kg was used in all groups. The hemodynamic parameters were measured non\u2010invasively and the electrocardiographic parameters using the signal processing method.<\/jats:p><jats:p><jats:bold>Result:\u2002<\/jats:bold> The highest QTc values, which often exceeded the normal upper limit of 440\u2003ms, were recorded at the baseline or immediately after the administration of the induction drugs. The intervals were significantly shorter if esmolol was co\u2010administered with either propofol or metohexital. The heart rate increased in the group M and decreased in the group P\u2003+\u2003E but remained unchanged in the groups P and M\u2003+\u2003E. Systolic and diastolic arterial pressures decreased during the study in all groups, most prominently in group P\u2003+\u2003E.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> During the anesthesia induction, the QTc interval was significantly shorter when esmolol was co\u2010administered with either propofol or metohexital. The hemodynamic responses were properly controlled with the combination of metohexital and esmolol as well as with propofol alone, but the combination of propofol and esmolol tended to cause hemodynamic depression.<\/jats:p>","DOI":"10.1111\/j.1399-6576.2006.00911.x","type":"journal-article","created":{"date-parts":[[2006,1,18]],"date-time":"2006-01-18T13:01:42Z","timestamp":1137589302000},"page":"188-192","source":"Crossref","is-referenced-by-count":10,"title":["The electrocardiographic and hemodynamic effect of metohexital and propofol with and without esmolol"],"prefix":"10.1111","volume":"50","author":[{"given":"R.","family":"Korpinen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U\u2010M.","family":"Klemola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Simola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Toivonen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,1,18]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.1995.tb04082.x"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199412000-00013"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-198303000-00005"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.1990.tb03085.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.1983.tb01921.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.1995.tb04175.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03010706"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/78.6.642"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/69.2.172"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.1988.tb02796.x"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03014354"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/71.5.736"},{"key":"e_1_2_6_14_2","first-page":"123","article-title":"Effect of esmolol on the hemodynamic and electrocardiographic changes during laryngomicroscopy under propofol\u2010alfentanil anesthesia","volume":"49","author":"Korpinen R","year":"1998","journal-title":"Acta Anaesthesiol Belg"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03019809"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-199107000-00002"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199812000-00028"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199701000-00010"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-199402000-00029"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199812000-00028"}],"container-title":["Acta Anaesthesiologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1399-6576.2006.00911.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1399-6576.2006.00911.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T08:43:19Z","timestamp":1696927399000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1399-6576.2006.00911.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1,18]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,2]]}},"alternative-id":["10.1111\/j.1399-6576.2006.00911.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1399-6576.2006.00911.x","archive":["Portico"],"relation":{},"ISSN":["0001-5172","1399-6576"],"issn-type":[{"value":"0001-5172","type":"print"},{"value":"1399-6576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,1,18]]}}}