{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T13:17:31Z","timestamp":1780406251245,"version":"3.54.1"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,2,14]],"date-time":"2006-02-14T00:00:00Z","timestamp":1139875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2006,3]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> Plasma B\u2010type natriuretic peptide (BNP) assay is recommended as a diagnostic tool in emergency\u2010room patients with acute dyspnea. In the intensive care unit (ICU), the utility of this peptide remains a matter of debate. The objectives of this study were to determine whether cut\u2010off values for BNP and N\u2010terminal\u2010proBNP (NT\u2010proBNP) reliably diagnosed right and\/or left ventricular failure in patients with shock or acute respiratory distress, and whether non\u2010cardiac factors led to an increase in these markers.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Plasma BNP and NT\u2010proBNP levels and echocardiographic parameters of cardiac dysfunction were determined in 41 patients within 24\u2003h of the onset of shock or acute respiratory distress.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> BNP and NT\u2010proBNP levels were higher in the 25 patients with heart failure than in the other 16 patients: 491.7\u2003\u00b1 418\u2003pg\/ml vs. 144.3\u2003\u00b1\u2003128\u2003pg\/ml and 2874.4\u2003\u00b1\u20032929\u2003pg\/ml vs. 762.7\u2003\u00b1\u20031128\u2003pg\/ml, respectively (<jats:italic>P\u2003&lt;<\/jats:italic>\u20030.05). In the diagnosis of cardiac dysfunction, BNP\u2003&gt;\u2003221\u2003pg\/ml and NT\u2010proBNP &gt;\u2003443\u2003pg\/ml had 68% and 84% sensitivity, respectively, and 88% and 75% specificity, respectively, but there was a substantial overlap of BNP and NT\u2010proBNP values between patients with and without heart failure. BNP and NT\u2010proBNP were elevated, but not significantly, in patients with isolated right ventricular dysfunction. Patients with renal dysfunction and normal heart function had significantly higher levels of BNP (258.6\u2003\u00b1\u2003144\u2003pg\/ml vs. 92.4\u2003\u00b1\u200384\u2003pg\/ml) and NT\u2010proBNP (2049\u2003\u00b1\u20031320\u2003pg\/ml vs. 118\u2003\u00b1\u2003104\u2003pg\/ml) than patients without renal dysfunction.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Both BNP and NT\u2010proBNP can help in the diagnosis of cardiac dysfunction in ICU patients, but cannot replace echocardiography. An elevated BNP or NT\u2010proBNP level merely indicates the presence of a \u2018cardiorenal distress\u2019 and should prompt further investigation.<\/jats:p>","DOI":"10.1111\/j.1399-6576.2006.00963.x","type":"journal-article","created":{"date-parts":[[2006,2,14]],"date-time":"2006-02-14T17:18:00Z","timestamp":1139937480000},"page":"340-347","source":"Crossref","is-referenced-by-count":32,"title":["B\u2010type natriuretic peptide (BNP) and N\u2010terminal\u2010proBNP for heart failure diagnosis in shock or acute respiratory distress"],"prefix":"10.1111","volume":"50","author":[{"given":"L.","family":"Bal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Thierry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Brocas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Van de Louw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Pottecher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Hours","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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