{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:09:11Z","timestamp":1760954951443},"reference-count":22,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2006,8,21]],"date-time":"2006-08-21T00:00:00Z","timestamp":1156118400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> The administration of insulin has been shown to exert cardioprotective and immunomodulatory properties. Ischemia and inflammation are typical features of acute coronary syndrome, thus it was hypothesized that high\u2010dose glucose\u2013insulin\u2013potassium (GIK) treatment could suppress the systemic inflammatory reaction and attenuate myocardial ischemia\u2013reperfusion injury in patients with unstable angina pectoris after urgent coronary artery bypass surgery.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Forty patients with unstable angina pectoris scheduled for urgent coronary artery bypass surgery and cardiopulmonary bypass were randomly assigned to receive either high\u2010dose insulin treatment (short\u2010acting insulin 1 IU\/kg\/h with 30% glucose 1.5 ml\/kg\/h administered separately) or control treatment (saline). Blood glucose levels were targeted to 6.0\u20138.0 mmol\/l in both groups by adjusting the rate of glucose infusion in the GIK group and by additional insulin in the control group as needed.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> High\u2010dose insulin treatment was associated with significantly lower average C\u2010reactive protein (23.8 vs. 40.1 mg\/l, <jats:italic>P<\/jats:italic>= 0.008) and free fatty acid levels (0.22 vs. 0.41 mmol\/l, <jats:italic>P<\/jats:italic>= &lt; 0.001) post\u2010operatively. Average blood glucose levels were comparable during the intensive care unit (ICU) stay (7.1 vs. 6.9 mmol\/l, <jats:italic>P<\/jats:italic>= 0.5) and 95% of the control patients received supplemental insulin. The pro\u2010inflammatory cytokine response [interleukin\u20106 (IL\u20106), interleukin\u20108 (IL\u20108) and tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1)] did not differ between the groups and beneficial effects on myocardial injury were not detected.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> High\u2010dose insulin treatment has potential anti\u2010inflammatory properties independent of its ability to lower blood glucose levels. Even profound suppression of free fatty acid levels, the attenuation of myocardial ischemia\u2013reperfusion injury was not detected.<\/jats:p>","DOI":"10.1111\/j.1399-6576.2006.01100.x","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T18:13:40Z","timestamp":1171995220000},"page":"962-969","source":"Crossref","is-referenced-by-count":37,"title":["Anti\u2010inflammatory effect of high\u2010dose insulin treatment after urgent coronary revascularization surgery"],"prefix":"10.1111","volume":"50","author":[{"given":"J. K.","family":"Koskenkari","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. 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