{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T09:35:20Z","timestamp":1771061720076,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2006,9,20]],"date-time":"2006-09-20T00:00:00Z","timestamp":1158710400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> We report a case of a 69\u2010year\u2010old Caucasian male who experienced a severe drop in blood pressure and a skin rash after fluorescence cystoscopy and transurethral resection of the prostate. The diagnostic agent used for fluorescence cystoscopy and suspected of causing the anaphylaxis was hexaminolevulinate hydrochloride (Hexvix<jats:sup>\u00ae<\/jats:sup>).<\/jats:p><jats:p><jats:bold>Incident:\u2002<\/jats:bold> A profound fall in blood pressure associated with atrial fibrillation, the appearance of a rash, vomiting and transient loss of consciousness occurred immediately after surgery. The hypotension persisted for several hours despite intensive treatment. The reaction commenced approximately 5 h after exposure to Hexvix<jats:sup>\u00ae<\/jats:sup>. There was an increase in serum tryptase (almost nine\u2010fold) and a positive skin prick test to undiluted Hexvix<jats:sup>\u00ae<\/jats:sup>.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> The mechanism of the anaphylaxis is uncertain, but is considered likely to be a non\u2010immunoglobulin E\u2010mediated allergic reaction possibly caused by Hexvix<jats:sup>\u00ae<\/jats:sup>. This is the first reported case of a severe allergic reaction after intravesical instillation of Hexvix<jats:sup>\u00ae<\/jats:sup>.<\/jats:p>","DOI":"10.1111\/j.1399-6576.2006.01110.x","type":"journal-article","created":{"date-parts":[[2006,9,20]],"date-time":"2006-09-20T09:52:21Z","timestamp":1158745941000},"page":"1165-1167","source":"Crossref","is-referenced-by-count":15,"title":["A case of anaphylactic shock possibly caused by intravesical Hexvix<sup>\u00ae<\/sup>"],"prefix":"10.1111","volume":"50","author":[{"given":"L.","family":"Colapaoli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Thorsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Nopp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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