{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T13:11:39Z","timestamp":1773321099661,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2006,9,20]],"date-time":"2006-09-20T00:00:00Z","timestamp":1158710400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> Acute lung injury (ALI) is a progressive syndrome associated with significant mortality in sepsis patients. Neutrophils are key cells in the inflammatory response that characterizes ALI. This study was designed to explore the effects of hydroxyethyl starch (HES) 130\/0.4 (a novel plasma substitute) on pulmonary neutrophil recruitment and associated ALI in a rat sepsis model induced by cecal ligation and puncture (CLP).<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Animals were randomly assigned to six groups [saline control; CLP and saline; CLP and HES (7.5, 15 and 30 ml\/kg); and HES control], subjected to CLP and infused with or without HES 130\/0.4 4 h after CLP. Six hours later, the pulmonary capillary permeability (PCP), myeloperoxidase (MPO) activity, lung histological changes, tumor necrosis factor\u2010\u03b1, interleukin\u20101\u03b2 and cytokine\u2010induced neutrophil chemoattractant levels, P\u2010selectin mRNA expression and nuclear factor\u2010kappa B (NF\u2010\u03baB) activation were measured.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Resuscitation with HES 130\/0.4 significantly attenuated the CLP\u2010induced increase in PCP, MPO activity, cytokine\/chemokine levels, mRNA expression of P\u2010selectin and NF\u2010\u03baB activation, all of which are involved in the recruitment of neutrophils. Groups receiving the higher doses of HES 130\/0.4 (15 and 30 ml\/kg) were more adequately resuscitated.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> HES 130\/0.4 can inhibit CLP\u2010induced neutrophil recruitment and subsequent ALI by attenuating cytokines\/chemokines, adhesion molecule\u2010mediated inflammation and NF\u2010\u03baB activation.<\/jats:p>","DOI":"10.1111\/j.1399-6576.2006.01113.x","type":"journal-article","created":{"date-parts":[[2006,9,20]],"date-time":"2006-09-20T09:52:21Z","timestamp":1158745941000},"page":"1081-1088","source":"Crossref","is-referenced-by-count":25,"title":["Influence of hydroxyethyl starch 130\/0.4 in pulmonary neutrophil recruitment and acute lung injury during polymicrobial sepsis in 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