{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T23:04:26Z","timestamp":1784070266048,"version":"3.55.0"},"reference-count":19,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2006,8,25]],"date-time":"2006-08-25T00:00:00Z","timestamp":1156464000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> Stroke volume variation (SVV) \u2013 as measured by the pulse contour cardiac output (PiCCO<jats:sup>\u00ae<\/jats:sup>) system \u2013 predicts the cardiac output response to a fluid challenge in patients on controlled ventilation. Whether this applies to patients on pressure support ventilation is unknown.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Thirty consecutive patients with septic shock were included. All were on pressure support ventilation, monitored using the PiCCO<jats:sup>\u00ae<\/jats:sup> system and receiving 500 ml of colloid on clinical indications. Arterial pulse contour SVV and the transpulmonary thermodilution cardiac index were measured before and after fluid challenge.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Forty\u2010seven per cent of the patients were defined as fluid responders by an observed increase of &gt; 10% in the cardiac index after fluid. Prior to fluid challenge, the cardiac index was lower in responders compared with non\u2010responders (mean \u00b1 SD, 3.0 \u00b1 0.6 vs. 4.0 \u00b1 1.2 l\/min\/m<jats:sup>2<\/jats:sup>, <jats:italic>P &lt; <\/jats:italic>0.01). In contrast, pre\u2010infusion values of SVV were similar between subsequent responders and non\u2010responders (13 \u00b1 5 vs. 16 \u00b1 6%, <jats:italic>P =<\/jats:italic>0.26). The mean areas under the ROC curves were 0.77 (95% confidence interval, 0.60\u20130.94) and 0.52 (0.30\u20130.73) for pre\u2010fluid cardiac index and SVV, respectively, indicating a predictive power of only the cardiac index.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> SVV did not predict the response in cardiac output to fluid challenge in patients with septic shock on pressure support ventilation.<\/jats:p>","DOI":"10.1111\/j.1399-6576.2006.01120.x","type":"journal-article","created":{"date-parts":[[2006,8,25]],"date-time":"2006-08-25T17:44:23Z","timestamp":1156527863000},"page":"1068-1073","source":"Crossref","is-referenced-by-count":73,"title":["Stroke volume variation does not predict fluid responsiveness in patients with septic shock on pressure support ventilation"],"prefix":"10.1111","volume":"50","author":[{"given":"A.","family":"Perner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Faber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,8,25]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-002-1615-9"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ccx.0000158848.56107.b1"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0265021504002091"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-200104000-00034"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000053237.29264.01"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.128.2.848"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/88.1.124"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-002-1211-z"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0265021505001092"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aei262"},{"key":"e_1_2_5_12_2","doi-asserted-by":"crossref","unstructured":"American College of Chest Physicians\/Society of Critical Care Medicine Consensus Conference.Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis.Crit Care Med1992;20:864\u201374.","DOI":"10.1097\/00003246-199206000-00025"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199907000-00008"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01709751"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.124.5.1900"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000182801.48137.13"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000182899.42273.4E"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199812000-00007"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.162.1.9903035"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-005-2586-4"}],"container-title":["Acta Anaesthesiologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1399-6576.2006.01120.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1399-6576.2006.01120.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T07:41:16Z","timestamp":1696923676000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1399-6576.2006.01120.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8,25]]},"references-count":19,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2006,10]]}},"alternative-id":["10.1111\/j.1399-6576.2006.01120.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1399-6576.2006.01120.x","archive":["Portico"],"relation":{},"ISSN":["0001-5172","1399-6576"],"issn-type":[{"value":"0001-5172","type":"print"},{"value":"1399-6576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,8,25]]}}}