{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T05:40:34Z","timestamp":1697002834024},"reference-count":14,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2006,9,20]],"date-time":"2006-09-20T00:00:00Z","timestamp":1158710400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> Airway irritation is a major drawback of desflurane anesthesia. This study was designed to evaluate the effect of intravenous fentanyl given before thiopental induction on airway irritation caused by a stepwise increase in desflurane in children.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Eighty children (2\u20138 years) were enrolled in a randomized, double\u2010blind study. Forty received saline and 40 received 2 \u03bcg\/kg of fentanyl intravenously; this was followed by thiopental sodium 5 mg\/kg in both groups. Patients were assistant\u2010ventilated with desflurane 1%, which was then increased by 1% every six breaths up to 10%. During this period, cough, secretion, excitation and apnea were graded and the desflurane concentration at which airway irritation symptoms first occurred was recorded. The results were analyzed using Pearson\u2019s chi\u2010squared test.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> The incidence of typical airway irritation events was lower with fentanyl than with saline (cough, 2.5% vs. 42.5%; secretion, 27.5% vs. 82.5%; excitation, 10% vs. 82.5%; apnea, 20% vs. 65%; <jats:italic>P <\/jats:italic>&lt; 0.05). The mean expired desflurane concentration at which the first airway irritation symptom occurred was greater with fentanyl than with saline (7.3% vs. 5.5%, <jats:italic>P <\/jats:italic>&lt; 0.05).<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Intravenous fentanyl in children reduces airway complications caused by desflurane.<\/jats:p>","DOI":"10.1111\/j.1399-6576.2006.01134.x","type":"journal-article","created":{"date-parts":[[2006,9,20]],"date-time":"2006-09-20T09:52:21Z","timestamp":1158745941000},"page":"1161-1164","source":"Crossref","is-referenced-by-count":13,"title":["Fentanyl reduces desflurane\u2010induced airway irritability following thiopental administration in children"],"prefix":"10.1111","volume":"50","author":[{"given":"J.","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Oh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,9,20]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"971","article-title":"Partition coefficient of I\u2010653 in human blood, saline, and olive oil","volume":"6","author":"Eger EI","year":"1987","journal-title":"Anesth Analg"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199203000-00009"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03008665"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/85.3.364"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-199709000-00036"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000146514.65070.AE"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-197011000-00020"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1006\/pulp.1996.0046"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199806000-00007"},{"key":"e_1_2_6_11_2","first-page":"1199","volume-title":"Clinical Anesthesia","author":"Joseph PC","year":"2001"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-200107000-00019"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-200205000-00023"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003643-200407000-00006"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-199604000-00025"}],"container-title":["Acta Anaesthesiologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1399-6576.2006.01134.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1399-6576.2006.01134.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T07:40:51Z","timestamp":1696923651000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1399-6576.2006.01134.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,9,20]]},"references-count":14,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2006,10]]}},"alternative-id":["10.1111\/j.1399-6576.2006.01134.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1399-6576.2006.01134.x","archive":["Portico"],"relation":{},"ISSN":["0001-5172","1399-6576"],"issn-type":[{"value":"0001-5172","type":"print"},{"value":"1399-6576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,9,20]]}}}