{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T19:50:19Z","timestamp":1762113019280},"reference-count":27,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2006,9,20]],"date-time":"2006-09-20T00:00:00Z","timestamp":1158710400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> There are various hydroxyethyl starch (HES) solutions with different degrees of hydroxylation and different molecular weights. HES200\/0.5 solution is most commonly used. HES130\/0.4 is a new HES solution and is the \u2018state\u2010of\u2010the\u2010art\u2019 in volume substitution. However, the mechanism of the observed anticoagulation action of HES has not been fully delineated. The objective of this study was to further investigate the effect of HES200\/0.5 and HES130\/0.4 on platelet coagulation.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Sixty ASA I\u2013II patients undergoing elective minor surgery were randomly allocated to receive an intravenous infusion (20 ml\/kg) of lactated Ringer\u2019s solution (group L), HES200\/0.5 (group H) or HES130\/0.4 (group V) after the induction of anesthesia. The expression of CD42b, CD41\/61 and CD62p <jats:italic>in vivo <\/jats:italic>was assessed on non\u2010stimulated platelets and adenosine diphosphate (ADP) agonist\u2010activated platelets using flow cytometry.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Resting glycoprotein expression of the non\u2010stimulated platelets was observed. HES200\/0.5 and HES130\/0.4 reduced the CD42b, CD41\/61 and CD62p expression of ADP\u2010agonist\u2010activated platelets at 15 min after intravenous infusion. At 6 h after intravenous infusion, the trend of decreasing expression of activated CD42b, CD41\/61 and CD62p was maintained in group H. However, CD42b, CD41\/61 and CD62p expression returned to the pre\u2010operative level in group V.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> This study showed that both HES200\/0.5 and HES130\/0.4 can inhibit platelet coagulation. Platelet dysfunction experienced a faster recovery after the infusion of HES130\/0.4 than after HES200\/0.5. Liquid resuscitation with HES130\/0.4 may decrease the risk of hemorrhage in the operative period.<\/jats:p>","DOI":"10.1111\/j.1399-6576.2006.01138.x","type":"journal-article","created":{"date-parts":[[2006,9,20]],"date-time":"2006-09-20T09:52:21Z","timestamp":1158745941000},"page":"1089-1094","source":"Crossref","is-referenced-by-count":17,"title":["Effects of two different hydroxyethyl starch solutions (HES200\/0.5 vs. HES130\/0.4) on the expression of platelet membrane glycoprotein"],"prefix":"10.1111","volume":"50","author":[{"given":"G.","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Q. 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