{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:09:29Z","timestamp":1760954969428},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2007,4,5]],"date-time":"2007-04-05T00:00:00Z","timestamp":1175731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2007,5]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> In a porcine model, the cardioprotective effect of sevoflurane was studied with regard to the preservation of myocardial contractility (myocardial stunning) after a myocardial ischaemic insult.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Twenty\u2010seven pigs were randomized to receive either a dual 4% sevoflurane inhalation period as a supplement to pentobarbital anaesthesia or pentobarbital anaesthesia only before a 15\u2010min ischaemic insult on the left anterior descending coronary artery. The ischaemic period was followed by 180 min of reperfusion. Myocardial contractility was assessed by myocardial sonomicrometry.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> A significant difference was found between the sevoflurane group and the control group at 5 min of reperfusion. However, subsequently, there was no overall difference between the two groups.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Sevoflurane administered as a pre\u2010ischaemic bolus does not provide long\u2010term improvement of the myocardial contractility. However, it can be speculated that sevoflurane may induce an early improvement in contractility.<\/jats:p>","DOI":"10.1111\/j.1399-6576.2007.01288.x","type":"journal-article","created":{"date-parts":[[2007,4,5]],"date-time":"2007-04-05T23:24:21Z","timestamp":1175815461000},"page":"577-581","source":"Crossref","is-referenced-by-count":6,"title":["Does the pre\u2010ischaemic administration of sevoflurane reduce myocardial stunning? A porcine experimental model"],"prefix":"10.1111","volume":"51","author":[{"given":"S.","family":"Aagaard","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. R.","family":"Larsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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