{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T20:38:24Z","timestamp":1788467904119,"version":"build-2803163510"},"reference-count":19,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2007,5,4]],"date-time":"2007-05-04T00:00:00Z","timestamp":1178236800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2007,8]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> Empirical off\u2010label use of recombinant activated factor VII (rFVIIa) has been reported to be effective in some cases of severe postpartum haemorrhage (PPH). Successful management of these patients has lead to more wide\u2010spread use of rFVIIa in less severe cases without any evidence for the advantages of its administration.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Until November 2006, we had administered rFVIIa to 38 parturients. Based on our initial experience with the first 12 patients, we prepared guidelines for the use of rFVIIa. During the existence of these guidelines, we made a retrospective comparison of the 26 women who received rFVIIa with another 22 women who were treated during the same time period without using rFVIIa.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> The total amount of blood loss was significantly higher (11.3 \u00b1 4.5 vs. 8.0 \u00b1 3.1 l), and the coagulation screen revealed significantly longer partial thromboplastin time (APTT) and prothrombin time (PT) values and significantly lower fibrinogen values in patients receiving rFVIIa. The need for red blood cells, platelets and fibrinogen concentrate was significantly higher in these women. Although the response was considered good in two\u2010thirds of the women, several patients received rFVIIa with a poor or no response as a result of arterial bleeding.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> The decision to use rFVIIa resulted from a more profound haemorrhage. We did not gain any evidence to extend the use of rFVIIa into less severe cases of PPH. Furthermore, this policy would result in a profound increase in the overall costs of the treatment. Randomized placebo\u2010controlled trials are urgently needed to optimize the use of rFVIIa in obstetric haemorrhage.<\/jats:p>","DOI":"10.1111\/j.1399-6576.2007.01323.x","type":"journal-article","created":{"date-parts":[[2007,5,9]],"date-time":"2007-05-09T07:15:05Z","timestamp":1178694905000},"page":"929-936","source":"Crossref","is-referenced-by-count":47,"title":["An open non\u2010randomized study of recombinant activated factor VII in major postpartum haemorrhage"],"prefix":"10.1111","volume":"51","author":[{"given":"J.","family":"Ahonen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Jokela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Korttila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,5,4]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001703-200112000-00008"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.curobgyn.2003.12.004"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2001.02878.x"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-200306000-00008"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeh196"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aei094"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijoa.2006.07.005"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200401000-00009"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7933.2003.00617.x"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000193624.28251.83"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aei160"},{"key":"e_1_2_5_13_2","first-page":"1114","volume-title":"Cardiac anesthesia","author":"Horrow J","year":"1999"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000134800.46276.21"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000017219.83330.FF"},{"key":"e_1_2_5_16_2","unstructured":"HaynesK StoneC KingJ.Major morbidities associated with childbirth in Victoria: obstetric haemorrhage and associated hysterectomy[WWW document]. Melbourne:Public Heath Group. Department of Human Services 2004. URLwww.health.vic.gov.au\/maternitycare[accessed on March 1 2007]."},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000245445.36116.c6"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1538-7836.2003.00009.x"},{"key":"e_1_2_5_19_2","first-page":"669","volume-title":"Obstetric anesthesia","author":"Mayer DC","year":"2004"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005373-200109000-00002"}],"container-title":["Acta Anaesthesiologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1399-6576.2007.01323.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1399-6576.2007.01323.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T16:47:42Z","timestamp":1696870062000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1399-6576.2007.01323.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,5,4]]},"references-count":19,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2007,8]]}},"alternative-id":["10.1111\/j.1399-6576.2007.01323.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1399-6576.2007.01323.x","archive":["Portico"],"relation":{},"ISSN":["0001-5172","1399-6576"],"issn-type":[{"value":"0001-5172","type":"print"},{"value":"1399-6576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,5,4]]}}}