{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:34:59Z","timestamp":1791218099254,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2007,9,10]],"date-time":"2007-09-10T00:00:00Z","timestamp":1189382400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2007,10]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> Hypothermia has been proposed as a therapeutic possibility in brain trauma, cardiac arrest and hemorrhagic shock. Experimental studies have shown that hypothermia may act by modulating the inflammatory response during endotoxemia. This study was carried out to test whether hypothermia could protect rats from endotoxemic insult.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> After general anesthesia and oro\u2010tracheal intubation, Sprague\u2013Dawley rats were randomly assigned to either a hypothermic group or normothermic group. In each group, rats received intraperitoneal lipopolysaccharide (LPS) (10 or 20\u2003mg\/kg). Blood samples were taken prior to and 2\u2003h after LPS injection to measure blood gases, liver enzymes, muscular enzymes, tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1) and interleukin\u201010 (IL\u201010) plasma levels. After 2\u2003h of hypothermia, the rats were extubated and brought back to their cages. The mortality rate was observed for 7\u2003days following endotoxemia. In a second set of experiments, hypothermia was induced 1\u2003h after endotoxemia (10\u2003mg\/kg of intraperitoneal LPS) and the mortality rate was observed for the following 7\u2003days.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> The survival rate was significantly increased in the hypothermic group relative to the normothermic group, regardless of LPS dose. This increased survival rate was also observed when hypothermia was induced 1\u2003h after endotoxemia. In the hypothermic group, IL\u201010 and the \u0394IL\u201010\/\u0394TNF\u2010\u03b1 ratio were significantly increased relative to those in the normothermic group.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Induced mild hypothermia reduces mortality during endotoxemia in rats. The modulation of the inflammatory response, with an increase in anti\u2010inflammatory cytokines, may be involved in this protective effect.<\/jats:p>","DOI":"10.1111\/j.1399-6576.2007.01419.x","type":"journal-article","created":{"date-parts":[[2010,8,12]],"date-time":"2010-08-12T14:56:22Z","timestamp":1281624982000},"page":"1211-1216","source":"Crossref","is-referenced-by-count":48,"title":["Induced mild hypothermia reduces mortality during acute inflammation in rats"],"prefix":"10.1111","volume":"51","author":[{"given":"O.","family":"Huet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Kinirons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Dupic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Lajeunie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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