{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T22:29:52Z","timestamp":1765837792236},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,11,1]],"date-time":"2007-11-01T00:00:00Z","timestamp":1193875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2008,1]]},"abstract":"<jats:p><jats:bold>Background: <\/jats:bold> It has been reported that, with deep levels of anesthesia achieved with general anesthetic agents and opioids, post\u2010operative consumption of morphine and pain intensity can be reduced. It is not clear whether the depth of anesthesia modifies pain intensity by influencing the endocrine\u2010metabolic stress response. The purpose of this study was to assess the influence of a high concentration of desflurane on peri\u2010operative plasma cortisol.<\/jats:p><jats:p><jats:bold>Methods: <\/jats:bold> The study was prospective and observer blinded, and included 20 women scheduled for elective total abdominal hysterectomy. They were randomly divided in to two groups: a deep group (D) (<jats:italic>n<\/jats:italic>=10) and a light group (L) (<jats:italic>n<\/jats:italic>=10). Anesthesia was induced with propofol, fentanyl and rocuronium: desflurane was administered at two different concentrations according to Bispectral Index monitoring (deep, 25 and light, 50). Post\u2010operative pain relief was achieved with patient\u2010controlled analgesia (PCA) with intravenous morphine. Blood samples were taken before, during and after surgery for the measurement of plasma cortisol, glucose and lactate. Post\u2010operative pain visual analog scale (VAS) and morphine consumption were recorded at regular intervals for the first 24\u2003h.<\/jats:p><jats:p><jats:bold>Results: <\/jats:bold> The Concentrations of plasma cortisol, glucose and lactate increased with surgery in both groups, and remained elevated, with no difference between the two groups. VAS and morphine consumptions were similar in both groups.<\/jats:p><jats:p><jats:bold>Conclusion: <\/jats:bold> The results show that there is no relationship between the intra\u2010operative level of anesthesia depth achieved with desflurane and the extent of endocrine\u2010metabolic stress response.<\/jats:p>","DOI":"10.1111\/j.1399-6576.2007.01470.x","type":"journal-article","created":{"date-parts":[[2010,6,25]],"date-time":"2010-06-25T14:44:57Z","timestamp":1277477097000},"page":"99-105","source":"Crossref","is-referenced-by-count":22,"title":["Depth of anesthesia with desflurane does not influence the endocrine\u2010metabolic response to pelvic surgery"],"prefix":"10.1111","volume":"52","author":[{"given":"G.","family":"BALDINI","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"BAGRY","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"CARLI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,11]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"813","article-title":"Effect of auditory evoked potential index monitoring on anesthetic drug requirements and recovery profile after laparoscopic surgery","volume":"99","author":"Recart A","year":"2003","journal-title":"a clinical utility study"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200204000-00003"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/82.5.672"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000130618.99860.48"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1142\/9781848160231_0030"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-6576.2003.00148.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2005.00598.x"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199403000-00017"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200109000-00007"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-198105000-00008"},{"key":"e_1_2_6_12_2","first-page":"1069","article-title":"New criteria for fast\u2010tracking after outpatient anesthesia","volume":"88","author":"White P","year":"1999","journal-title":"a comparison with the Modified Aldrete's scoring system"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.1993.tb03787.x"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200402000-00031"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/ael004"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200411000-00008"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/58.8.844"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-199108000-00007"}],"container-title":["Acta Anaesthesiologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1399-6576.2007.01470.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1399-6576.2007.01470.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T02:24:55Z","timestamp":1696904695000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1399-6576.2007.01470.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,11]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,1]]}},"alternative-id":["10.1111\/j.1399-6576.2007.01470.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1399-6576.2007.01470.x","archive":["Portico"],"relation":{},"ISSN":["0001-5172","1399-6576"],"issn-type":[{"value":"0001-5172","type":"print"},{"value":"1399-6576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,11]]}}}