{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:48:15Z","timestamp":1772160495313,"version":"3.50.1"},"reference-count":51,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2008,3,13]],"date-time":"2008-03-13T00:00:00Z","timestamp":1205366400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Pain following embolization of the uterine arteries (UAEs) is variable and may be very severe requiring large doses of parenteral opioids for relief. The present study tested the hypothesis that the addition of ketamine to IV patient\u2010controlled morphine reduces the amount of morphine required for pain\u2010control during the first 24\u2003h after UAE embolization.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    Fifty\u2010six patients undergoing UAE embolization for treatment of symptomatic uterine leiomyomata were randomized to receive either 2\u2003mg\/ml of morphine (Control group,\n                    <jats:italic>n<\/jats:italic>\n                    =30) or 2\u2003mg\/ml of both morphine and ketamine (Ketamine group,\n                    <jats:italic>n<\/jats:italic>\n                    =26) by IV patient\u2010controlled analgesia (IV\u2010PCA). Pump settings were bolus dose 1\u2003ml, lockout 10\u2003min, no background infusion. In addition, all patients received diclofenac and acetaminophen for pain relief. Pain scores, morphine consumption and adverse events like nausea, vomiting, itching, visual disturbances, anxiety, dreaming and hallucinations, if any, were recorded for 24\u2003h after embolization.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    The mean \u00b1 SD 24\u2010h consumption of patient\u2010controlled morphine was 38.3 \u00b1 21.0\u2003mg in the Ketamine group vs. 33.3 \u00b1 18.3\u2003mg in the Control group (NS). The difference between the means was 5.0\u2003mg (95% confidence interval: \u22125.7; 15.6). One patient in the Ketamine group vs. none in the Control group experienced auditory hallucinations.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    Studying an unselected group of patients undergoing embolization of the UAEs for treatment of symptomatic uterine leiomyomata under conditions of basal analgesia with acetaminophen and diclofenac, we failed to demonstrate any morphine\u2010sparing effect of IV\u2010PCA ketamine and morphine compared with IV\u2010PCA morphine alone.\n                  <\/jats:p>","DOI":"10.1111\/j.1399-6576.2008.01602.x","type":"journal-article","created":{"date-parts":[[2009,1,15]],"date-time":"2009-01-15T16:43:41Z","timestamp":1232037821000},"page":"479-486","source":"Crossref","is-referenced-by-count":23,"title":["No morphine sparing effect of ketamine added to morphine for patient\u2010controlled intravenous analgesia after uterine artery embolization"],"prefix":"10.1111","volume":"52","author":[{"given":"L. 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