{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T00:39:43Z","timestamp":1698712783754},"reference-count":22,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2008,5,20]],"date-time":"2008-05-20T00:00:00Z","timestamp":1211241600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2008,8]]},"abstract":"<jats:p><jats:bold>Background: <\/jats:bold> We have previously reported that mivazerol, a \u03b1<jats:sub>2<\/jats:sub>\u2010agonist, possibly provides neuroprotection against transient forebrain ischemia in rats. This study was designed to investigate the ability of mivazerol to attenuate ischemia\u2010induced increase in striatal norepinephrine concentration after transient forebrain ischemia in rats.<\/jats:p><jats:p><jats:bold>Methods: <\/jats:bold> Male Sprague\u2013Dawley rats, anesthetized with halothane, were assigned to one of three groups (<jats:italic>n<\/jats:italic>=10 each); control (C, normal saline 1\u2003ml\/kg), mivazerol 20\u2003\u03bcg\/kg (M20), and 40\u2003\u03bcg\/kg (M40) groups. Monitored variables included temporal muscle temperature (maintained at 37.5\u00b10.1\u2003\u00b0C), electroencephalogram, systolic\/diastolic blood pressure, heart rate, arterial blood gases, and blood glucose concentrations. Thirty minutes after subcutaneous drug administration, forebrain ischemia was induced with hemorrhagic hypotension (systolic arterial pressure: 40\u201350\u2003mmHg) and bilateral carotid artery occlusion for 10\u2003min, and then the brain was reperfused. Norepinephrine concentration in the interstitial fluids in the striatum was analyzed using <jats:italic>in vivo<\/jats:italic> microdialysis in combination with high\u2010performance liquid chromatography.<\/jats:p><jats:p><jats:bold>Results: <\/jats:bold> Ischemia resulted in a prompt increase in norepinephrine concentrations in the striatum in all groups. However, there were no significant differences in norepinephrine concentrations in the striatum between the three groups at any period.<\/jats:p><jats:p><jats:bold>Conclusions: <\/jats:bold> Our results indicate that mivazerol did not attenuate ischemia\u2010induced increase in striatal norepinephrine concentration. This suggests that the possible neuroprotective property of mivazerol is not related to inhibition of norepinephrine release in the brain.<\/jats:p>","DOI":"10.1111\/j.1399-6576.2008.01683.x","type":"journal-article","created":{"date-parts":[[2010,8,12]],"date-time":"2010-08-12T14:50:40Z","timestamp":1281624640000},"page":"997-1002","source":"Crossref","is-referenced-by-count":2,"title":["Effect of mivazerol, a \u03b1<sub>2<\/sub>\u2010agonist, on striatal norepinephrine concentration during transient forebrain ischemia in rats<sup>*<\/sup>"],"prefix":"10.1111","volume":"52","author":[{"given":"T.","family":"KIMURA","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"SATO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"NISHIKAWA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"TOBE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"MASAKI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,7,9]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-199110000-00016"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199108000-00022"},{"key":"e_1_2_6_4_2","first-page":"1093","article-title":"Dexmedetomidine during coronary artery bypass grafting surgery","volume":"51","author":"Sulemaji DS","year":"2007","journal-title":"is it neuroprotective? \u2013 A preliminary study"},{"key":"e_1_2_6_5_2","first-page":"221","article-title":"Mivazerol, a novel compound with high binding specificity for \u03b12 adrenergic receptors","volume":"24","author":"Noyer M","year":"1994","journal-title":"binding studies on different human and rat membrane preparations"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00877729"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199702000-00010"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2005.00794.x"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199708000-00025"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1989.123"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01245121"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(93)90337-M"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200202000-00034"},{"key":"e_1_2_6_14_2","first-page":"1020","article-title":"Early appearance of activated matrix metalloproteinase\u20109 after focal cerebral ischemia in mice","volume":"19","author":"Gasche Y","year":"1999","journal-title":"a possible role in blood\u2013brain barrier dysfunction"},{"key":"e_1_2_6_15_2","first-page":"1661","article-title":"Effects of immobilization stress on hippocampal monoamine release","volume":"34","author":"Zhang X","year":"1995","journal-title":"modification by mivazerol, a new \u03b12-adrenoceptor agonist"},{"key":"e_1_2_6_16_2","first-page":"279","article-title":"The effect of halothane and isoflurane on neurologic outcome following incomplete cerebral ischemia in rat","volume":"76","author":"Hoffman WE","year":"1993","journal-title":"Anesth Analg"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-198808000-00007"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/83.3.415"},{"key":"e_1_2_6_19_2","first-page":"77","article-title":"\u03b12\u2010adrenoceptor agonists","volume":"71","author":"Ma D","year":"2004","journal-title":"shedding light on neuroprotection?"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2000-7082"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(96)00801-1"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-199502000-00011"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199503000-00003"}],"container-title":["Acta Anaesthesiologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1399-6576.2008.01683.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1399-6576.2008.01683.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T02:53:45Z","timestamp":1696906425000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1399-6576.2008.01683.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,7,9]]},"references-count":22,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2008,8]]}},"alternative-id":["10.1111\/j.1399-6576.2008.01683.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1399-6576.2008.01683.x","archive":["Portico"],"relation":{},"ISSN":["0001-5172","1399-6576"],"issn-type":[{"value":"0001-5172","type":"print"},{"value":"1399-6576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,7,9]]}}}