{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T18:11:05Z","timestamp":1776449465547,"version":"3.51.2"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2009,1,19]],"date-time":"2009-01-19T00:00:00Z","timestamp":1232323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2009,2]]},"abstract":"<jats:p><jats:bold>Background: <\/jats:bold> It has been suggested that propofol with ethylenediaminetetraacetic acid (EDTA) can modulate the systemic inflammatory response. Prolonged higher levels of pulmonary inflammation are associated with poor outcome of patients with acute lung injury. In the present study, we hypothesized that pulmonary inflammation could be modulated by propofol with EDTA compared with propofol with sulfite.<\/jats:p><jats:p><jats:bold>Methods: <\/jats:bold> Respiratory distress was induced in rats (<jats:italic>n<\/jats:italic>=25) by intratracheal nebulization of lipopolysaccharide (LPS). After 24\u2003h, animals were randomized to either propofol with EDTA (Propofol<jats:sub>EDTA<\/jats:sub>), propofol with sulfite (Propofol<jats:sub>sulfite<\/jats:sub>) or ketamine\/midazolam (Ket\/Mid); control animals received saline (<jats:italic>n<\/jats:italic>=30). Animals were ventilated for 4\u2003h and blood gases were measured hourly. Bronchoalveolar lavage (BAL) was performed for cytokine analysis of: tumor necrosis factor (TNF), interleukin (IL)\u20106 and macrophage inflammatory protein (MIP)\u20102.<\/jats:p><jats:p><jats:bold>Results: <\/jats:bold> LPS led to increased pulmonary inflammation in all groups compared with the control groups. Gas exchange deteriorated over time only in the LPS Propofol<jats:sub>sulfite<\/jats:sub> group and was significantly lower than the Ket\/Mid group. Only IL\u20106 was significantly higher in the LPS Propofol<jats:sub>sulfite<\/jats:sub> group compared with both the Ket\/Mid group and the Propofol<jats:sub>EDTA<\/jats:sub> group.<\/jats:p><jats:p><jats:bold>Conclusion: <\/jats:bold> Pulmonary IL\u20106 can be modulated by additives in systemic anesthesia.<\/jats:p><jats:p><jats:bold>Implication Statement: <\/jats:bold> This study demonstrates that pulmonary inflammation caused by direct lung injury can be modulated by intravenous anesthesia used in critically ill patients.<\/jats:p>","DOI":"10.1111\/j.1399-6576.2008.01844.x","type":"journal-article","created":{"date-parts":[[2009,1,19]],"date-time":"2009-01-19T17:33:15Z","timestamp":1232386395000},"page":"176-182","source":"Crossref","is-referenced-by-count":25,"title":["Additives in intravenous anesthesia modulates pulmonary inflammation in a model of LPS\u2010induced respiratory distress"],"prefix":"10.1111","volume":"53","author":[{"given":"J. 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