{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T14:13:36Z","timestamp":1698761616274},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2009,1,23]],"date-time":"2009-01-23T00:00:00Z","timestamp":1232668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2009,3]]},"abstract":"<jats:p><jats:bold>Background: <\/jats:bold> In obese patients, depth of anaesthesia monitoring could be useful in titrating intravenous anaesthetics. We hypothesized that depth of anaesthesia monitoring would reduce recovery time and use of anaesthetics in obese patients receiving propofol and remifentanil.<\/jats:p><jats:p><jats:bold>Methods: <\/jats:bold> We investigated 38 patients with a body mass index \u226530\u2003kg\/m<jats:sup>2<\/jats:sup> scheduled for an abdominal hysterectomy. Patients were randomized to either titration of propofol and remifentanil according to a cerebral state monitor (CSM group) or according to usual clinical criteria (control group). The primary end point was time to eye opening and this was assessed by a blinded observer.<\/jats:p><jats:p><jats:bold>Results: <\/jats:bold> Time to eye opening was 11.8\u2003min in the CSM group vs. 13.4\u2003min in the control group (<jats:italic>P<\/jats:italic>=0.58). The average infusion rate for propofol was a median of 516 vs. 617\u2003mg\/h (<jats:italic>P<\/jats:italic>=0.24) and for remifentanil 2393 vs. 2708\u2003\u03bcg\/h (<jats:italic>P<\/jats:italic>=0.04). During surgery, when the cerebral state index was continuously between 40 and 60, the corresponding optimal propofol infusion rate was 10\u2003mg\/kg\/h based on ideal body weight.<\/jats:p><jats:p><jats:bold>Conclusion: <\/jats:bold> No significant reduction in time to eye opening could be demonstrated when a CSM was used to titrate propofol and remifentanil in obese patients undergoing a hysterectomy. A significant reduction in remifentanil consumption was found.<\/jats:p>","DOI":"10.1111\/j.1399-6576.2008.01872.x","type":"journal-article","created":{"date-parts":[[2009,1,23]],"date-time":"2009-01-23T17:40:31Z","timestamp":1232732431000},"page":"369-375","source":"Crossref","is-referenced-by-count":9,"title":["Depth of anaesthesia monitoring in obese patients: a randomized study of propofol\u2013remifentanil"],"prefix":"10.1111","volume":"53","author":[{"given":"C. S.","family":"MEYHOFF","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. W.","family":"HENNEBERG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. G.","family":"J\u00d8RGENSEN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. R.","family":"G\u00c4TKE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. 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