{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T14:10:59Z","timestamp":1791727859835,"version":"4.3.4"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2009,2,23]],"date-time":"2009-02-23T00:00:00Z","timestamp":1235347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2009,5]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Low to moderate doses of vasopressin have been used in the treatment of cathecholamine\u2010dependent vasodilatory shock in sepsis or after cardiac surgery. We evaluated the effects of vasopressin on jejunal mucosal perfusion, gastric\u2010arterial\n                    <jats:italic>p<\/jats:italic>\n                    CO\n                    <jats:sub>2<\/jats:sub>\n                    gradient and the global splanchnic oxygen demand\/supply relationship in patients with vasodilatory shock after cardiac surgery.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    Eight mechanically ventilated patients, dependent on norepinephrine to maintain mean arterial pressure (MAP) \u226560\u2003mmHg because of septic\/post\u2010cardiotomy vasodilatory shock and multiple organ failure after cardiac surgery, were included. Vasopressin was sequentially infused at 1.2, 2.4 and 4.8\u2003U\/h for 30\u2010min periods. Norepinephrine was simultaneously decreased to maintain MAP at 75\u2003mmHg. At each infusion rate of vasopressin, data on systemic hemodynamics, jejunal mucosal perfusion, jejunal mucosal hematocrit and red blood cell velocity (laser Doppler flowmetry) as well as gastric\u2010arterial\n                    <jats:italic>p<\/jats:italic>\n                    CO\n                    <jats:sub>2<\/jats:sub>\n                    gradient (gastric tonometry) and splanchnic oxygen and lactate extraction (hepatic vein catheter) were obtained.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    The cardiac index, stroke volume index and systemic oxygen delivery decreased and systemic vascular resistance and systemic oxygen extraction increased significantly, while the heart rate or global oxygen consumption did not change with increasing vasopressin dose. Jejunal mucosal perfusion decreased and the arterial\u2010gastric\u2010mucosal\n                    <jats:italic>p<\/jats:italic>\n                    CO\n                    <jats:sub>2<\/jats:sub>\n                    gradient increased, while splanchnic oxygen or lactate extraction or mixed venous\u2013hepatic venous oxygen saturation gradient were not affected by increasing infusion rates of vasopressin.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    Infusion of low to moderate doses of vasopressin in patients with norepinephrine\u2010dependent vasodilatory shock after cardiac surgery induces an intestinal and gastric mucosal vasoconstriction.\n                  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