{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T04:55:10Z","timestamp":1761540910729},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2009,6,3]],"date-time":"2009-06-03T00:00:00Z","timestamp":1243987200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2009,9]]},"abstract":"<jats:p><jats:bold>Background: <\/jats:bold> Thrombocytopenia after cardiac operations is a common event in both adult and pediatric patients. Late thrombocytopenia (LTCP) is a less common event that is still without a well\u2010recognized cause. This study explores the role of heparin\u2010induced thrombocytopenia (HIT) and other factors (complexity of the operation, temperature management, and drug use) in determining LTCP.<\/jats:p><jats:p><jats:bold>Methods: <\/jats:bold> We conducted an observational study of 63 consecutive patients aged &lt;36 months operated with or without cardiopulmonary bypass (CPB). LTCP was defined as a platelet count &lt;100,000\u2003cells\/\u03bcl or &lt;50% of the pre\u2010operative count at any point in time between post\u2010operative days 5 and 10. A diagnostic test for heparin\u2010platelet factor 4 (PF4) antibodies was performed in patients with LTCP. Other pre\u2010 and post\u2010operative factors were investigated for their association with LTCP.<\/jats:p><jats:p><jats:bold>Results: <\/jats:bold> LTCP occurred in 15 (24%) patients. No patient had positive heparin\u2010PF4 antibodies. The lowest temperature on CPB was an independent predictor of LTCP, with a cut\u2010off value at 29\u2003\u00b0C (sensitivity 80%, specificity 70%). Other factors associated with LTCP were prolonged post\u2010operative use of unfractionated heparin and milrinone. LTCP was associated with increased post\u2010operative morbidity.<\/jats:p><jats:p><jats:bold>Conclusion: <\/jats:bold> LTCP was related to a combination of factors (operation severity, degree of hypothermia during CPB, prolonged use of unfractionated heparin, and milrinone). The individual contribution of each factor seems difficult to establish. However, the degree of hypothermia during CPB and drug\u2010associated effects were identified. HIT could be excluded in all cases.<\/jats:p>","DOI":"10.1111\/j.1399-6576.2009.02010.x","type":"journal-article","created":{"date-parts":[[2009,6,3]],"date-time":"2009-06-03T10:17:43Z","timestamp":1244024263000},"page":"1060-1067","source":"Crossref","is-referenced-by-count":7,"title":["Hypothermic cardiopulmonary bypass as a determinant of late thrombocytopenia following cardiac operations in pediatric 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