{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T15:06:49Z","timestamp":1748272009683},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2010,1,6]],"date-time":"2010-01-06T00:00:00Z","timestamp":1262736000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2010,5]]},"abstract":"<jats:p><jats:bold>Background: <\/jats:bold> Ventilation with high positive end\u2010expiratory pressure (PEEP) can lead to liver dysfunction. We hypothesized that an open lung concept (OLC) using high PEEP impairs liver function and integrity dependent on the stabilization of cardiac output.<\/jats:p><jats:p><jats:bold>Methods: <\/jats:bold> Juvenile female Pietrain pigs instrumented with flow probes around the common hepatic artery and portal vein, pulmonary and hepatic vein catheters underwent a lavage\u2010induced lung injury. Ventilation was continued with a conventional approach (CON) using pre\u2010defined combinations of PEEP and inspiratory oxygen fraction or with an OLC using PEEP set above the lower inflection point of the lung. Volume replacement with colloids was guided to maintain cardiac output in the CON(V+) and OLC(V+) groups or acceptable blood pressure and heart rate in the OLC(V\u2212) group. Indocyanine green plasma disappearance rate (ICG\u2010PDR), blood gases, liver\u2010specific serum enzymes, bilirubin, hyaluronic acid and lactate were tested. Finally, liver tissue was examined for neutrophil accumulation, TUNEL staining, caspase\u20103 activity and heat shock protein 70 mRNA expression.<\/jats:p><jats:p><jats:bold>Results: <\/jats:bold> Hepatic venous oxygen saturation was reduced to 18 \u00b1 16% in the OLC(V\u2212) group, while portal venous blood flow decreased by 45%. ICG\u2010PDR was not reduced and serum enzymes, bilirubin and lactate were not elevated. Liver cell apoptosis was negligible. Liver sinusoids in the OLC(V+) and OLC(V\u2212) groups showed about two\u2010 and fourfold more granulocytes than the CON(V+) group. Heat shock protein 70 tended to be higher in the OLC(V\u2212) group.<\/jats:p><jats:p><jats:bold>Conclusions: <\/jats:bold> Open lung ventilation elicited neutrophil infiltration, but no liver dysfunction even without the stabilization of cardiac output.<\/jats:p>","DOI":"10.1111\/j.1399-6576.2009.02192.x","type":"journal-article","created":{"date-parts":[[2010,1,6]],"date-time":"2010-01-06T16:45:10Z","timestamp":1262796310000},"page":"632-642","source":"Crossref","is-referenced-by-count":3,"title":["Hepatic effects of an open lung strategy and cardiac output restoration in an experimental lung injury"],"prefix":"10.1111","volume":"54","author":[{"given":"M.","family":"KREDEL","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. M.","family":"MUELLENBACH","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"HORNUNG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"SCHMIDT","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"LAQUA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"BREDERLAU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"ROEWER","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"WUNDER","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,4]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01694358"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200209000-00023"},{"key":"e_1_2_7_4_2","first-page":"637","article-title":"Ventilation strategy using low tidal volumes, recruitment maneuvers, and high positive end\u2010expiratory pressure for acute lung injury and acute respiratory distress syndrome","volume":"299","author":"Meade MO","year":"2008","journal-title":"a randomized controlled trial"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.121.5.1602"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.16.2104"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3700440"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0b013e318188b720"},{"key":"e_1_2_7_9_2","first-page":"267","article-title":"Jaundice in critical illness","volume":"32","author":"Brienza N","year":"2006","journal-title":"promoting factors of a concealed reality"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-198711000-00010"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.152.2.7633699"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/cc5674"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/139.3.682"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200005043421801"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2253-6-8"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000256891.45790.4d"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1159\/000121471"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.161.5.9809014"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199802053380602"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/82.6.838"},{"key":"e_1_2_7_21_2","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1152\/jappl.1987.62.4.1377","article-title":"Effects of positive end\u2010expiratory pressure on hepatic blood flow and performance","volume":"62","author":"Matuschak GM","year":"1987","journal-title":"J Appl Physiol"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199702000-00022"},{"key":"e_1_2_7_23_2","first-page":"2207","article-title":"Dehydroepiandrosterone","volume":"33","author":"Oberbeck R","year":"2007","journal-title":"a modulator of cellular immunity and heat shock protein 70 production during polymicrobial sepsis"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e318059362e"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00795.2002"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1186\/cc5717"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1097\/00024382-199611000-00009"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119468"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1186\/1476-5926-3-4"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8278(91)90856-7"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200405-652OC"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119054"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.12.7594"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1007\/s005950070018"},{"key":"e_1_2_7_35_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199309000-00011"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.1006\/jsre.1997.5216"}],"container-title":["Acta Anaesthesiologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1399-6576.2009.02192.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1399-6576.2009.02192.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T14:17:02Z","timestamp":1698761822000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1399-6576.2009.02192.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4]]},"references-count":35,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010,5]]}},"alternative-id":["10.1111\/j.1399-6576.2009.02192.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1399-6576.2009.02192.x","archive":["Portico"],"relation":{},"ISSN":["0001-5172","1399-6576"],"issn-type":[{"value":"0001-5172","type":"print"},{"value":"1399-6576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,4]]}}}