{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T13:30:10Z","timestamp":1780493410831,"version":"3.54.1"},"reference-count":18,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2010,9,14]],"date-time":"2010-09-14T00:00:00Z","timestamp":1284422400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2010,11]]},"abstract":"<jats:p><jats:bold>Background: <\/jats:bold> Intravenous lidocaine can be used intraoperatively for its analgesic and antihyperalgesic properties but local anaesthetics may also prolong the duration of action of neuromuscular blocking agents. We hypothesized that intravenous lidocaine would prolong the time to recovery of neuromuscular function after cisatracurium.<\/jats:p><jats:p><jats:bold>Methods: <\/jats:bold> Forty\u2010two patients were enrolled in this randomized, double\u2010blind, placebo\u2010controlled study. Before induction, patients were administered either a 1.5\u2003mg\/kg bolus of intravenous lidocaine followed by a 2\u2003mg\/kg\/h infusion or an equal volume of saline. Anaesthesia was induced and maintained using propofol and remifentanil infusions. After loss of consciousness, a 0.15\u2003mg\/kg bolus of cisatracurium was administered. No additional cisatracurium injection was allowed. Neuromuscular function was assessed every 20\u2003s using kinemyography. The primary endpoint was the time to spontaneous recovery of a train\u2010of\u2010four (TOF) ratio \u22650.9.<\/jats:p><jats:p><jats:bold>Results: <\/jats:bold> The time to spontaneous recovery of a TOF ratio \u22650.9 was 94 \u00b1 15\u2003min in the control group and 98 \u00b1 16\u2003min in the lidocaine group (<jats:italic>P<\/jats:italic>=0.27).<\/jats:p><jats:p><jats:bold>Conclusions: <\/jats:bold> No significant prolongation of spontaneous recovery of a TOF ratio \u22650.9 after cisatracurium was found in patients receiving intravenous lidocaine.<\/jats:p>","DOI":"10.1111\/j.1399-6576.2010.02304.x","type":"journal-article","created":{"date-parts":[[2010,9,14]],"date-time":"2010-09-14T15:03:53Z","timestamp":1284476633000},"page":"1192-1196","source":"Crossref","is-referenced-by-count":12,"title":["Effect of an intravenous infusion of lidocaine on cisatracurium\u2010induced neuromuscular block duration: a randomized\u2010controlled trial"],"prefix":"10.1111","volume":"54","author":[{"given":"G. 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