{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T16:22:10Z","timestamp":1700583730424},"reference-count":31,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2010,9,14]],"date-time":"2010-09-14T00:00:00Z","timestamp":1284422400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2010,11]]},"abstract":"<jats:p><jats:bold>Background: <\/jats:bold> Hydroxyethyl starches (HES) could differ with regard to the origin, and the influence on the coagulation of the raw material is unknown. This study compared the effects of a new potato\u2010derived HES with a maize\u2010derived HES and two crystalloid solutions.<\/jats:p><jats:p><jats:bold>Methods: <\/jats:bold> Whole blood from 10 healthy individuals was diluted by 20% and 40% using either non\u2010balanced potato\u2010derived HES 130\/0.42\/6\u2003:\u20031, non\u2010balanced maize\u2010derived HES 130\/0.4\/9\u2003:\u20031, isotonic saline or Ringer's lactate solution. Samples were analysed by thromboelastometry ROTEM<jats:sup>\u00ae<\/jats:sup>: Coagulation was initiated by acid ellagic [intrinsic thromboelastometry (INTEM)] or tissue factor (extrinsic thromboelastometry) with and without cytochalasin to determine the functional component of fibrinogen [cytochalasin\u2010<jats:sc>d<\/jats:sc>\u2010modified thromboelastometry (FIBTEM)]. Platelet count and fibrinogen activity were measured.<\/jats:p><jats:p><jats:bold>Results: <\/jats:bold> No effect of raw material was found as no difference was detected among the HES solutions. Whatever the solution, progressive haemodilution impaired haemostasis in a dose\u2010dependant manner: For INTEM, the clot formation time was increased up to 308% and the maximum clot firmness (MCF) was decreased down to 49%. As dilution increased, initiation of coagulation was also impaired. Thromboelastometric alterations were more severe with HES than with crystalloids, especially regarding fibrin polymerization explorations: MCF of FIBTEM was considerably reduced from 12[10\u201314] to 2[2\u20133]\u2003mm (<jats:italic>P<\/jats:italic>&lt;0.05). Fibrinogen activity and platelet count were reduced by dilution in a dose\u2010dependant manner and decreased similarly in all groups.<\/jats:p><jats:p><jats:bold>Conclusion: <\/jats:bold> Maize\u2010 and potato\u2010derived HES have similar effects on coagulation. Both the starch preparations tested lead to more severe haemostatic defects than crystalloids, and impairment of fibrin polymerization appears to be a leading determinant of this coagulopathy.<\/jats:p>","DOI":"10.1111\/j.1399-6576.2010.02306.x","type":"journal-article","created":{"date-parts":[[2010,9,14]],"date-time":"2010-09-14T15:04:11Z","timestamp":1284476651000},"page":"1241-1247","source":"Crossref","is-referenced-by-count":16,"title":["Maize\u2010 or potato\u2010derived hydroxyethyl starches: is there any thromboelastometric difference?"],"prefix":"10.1111","volume":"54","author":[{"given":"A.","family":"GODIER","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"DURAND","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"SMADJA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"JEANDEL","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"EMMERICH","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. M.","family":"SAMAMA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,9,14]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2008.01690.x"},{"key":"e_1_2_7_3_2","first-page":"1574","article-title":"Modern rapidly degradable hydroxyethyl starches","volume":"108","author":"Boldt J.","year":"2009","journal-title":"current concepts"},{"key":"e_1_2_7_4_2","first-page":"187","article-title":"Hydroxyethyl starches","volume":"111","author":"Westphal M","year":"2009","journal-title":"differentproducts \u2013 different effects"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200509000-00031"},{"key":"e_1_2_7_6_2","first-page":"1020","article-title":"Balanced hydroxyethylstarch preparations","volume":"26","author":"Boldt J","year":"2009","journal-title":"are they all the same? In-vitro thrombelastometry and whole blood aggregometry"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200408000-00055"},{"key":"e_1_2_7_8_2","first-page":"210","article-title":"Highly substituted hydroxyethyl starch (HES200\/0.62) leads to Type\u2010I von Willebrand syndrome after repeated administration","volume":"26","author":"Treib J","year":"1996","journal-title":"Haemostasis"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1985.25485273815.x"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001340050833"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2007.01497.x"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-200106000-00008"},{"key":"e_1_2_7_13_2","first-page":"554","article-title":"In vitro effects of gelatin solutions on platelet function","volume":"60","author":"Thaler U","year":"2005","journal-title":"a comparison with hydroxyethyl starch solutions"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2009.03460.x"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aep194"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aen353"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.2165\/00126839-200708040-00003"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01697545"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2257.2005.00681.x"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mbc.0000169225.31173.19"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1213\/ane.0b013e3181966675"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-199909000-00007"},{"key":"e_1_2_7_23_2","first-page":"425","article-title":"A new plasma\u2010adapted hydroxyethylstarch preparation","volume":"104","author":"Boldt J","year":"2007","journal-title":"in vitro coagulation studies using thrombelastography and whole blood aggregometry"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2044.1998.489-az0565.x"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1213\/ane.0b013e3181966675"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e31816c5c6c"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/ael191"},{"key":"e_1_2_7_28_2","first-page":"324","article-title":"Thrombelastographic whole blood clot formation after ex vivo addition of plasma substitutes","volume":"94","author":"Fenger\u2010Eriksen C","year":"2005","journal-title":"improvements of the induced coagulopathy with fibrinogen concentrate"},{"key":"e_1_2_7_29_2","first-page":"905","article-title":"Hemostatic changes after crystalloid or colloid fluid administration during major orthopedic surgery","volume":"105","author":"Mittermayr M","year":"2007","journal-title":"the role of fibrinogen administration"},{"key":"e_1_2_7_30_2","first-page":"795","article-title":"Fibrinogen substitution improves whole blood clot firmness after dilution with hydroxyethyl starch in bleeding patients undergoing radical cystectomy","volume":"7","author":"Fenger\u2010Eriksen C","year":"2009","journal-title":"a randomized, placebo-controlled clinical trial"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199905000-00007"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aen148"}],"container-title":["Acta Anaesthesiologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1399-6576.2010.02306.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1399-6576.2010.02306.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T12:50:33Z","timestamp":1698756633000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1399-6576.2010.02306.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,9,14]]},"references-count":31,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2010,11]]}},"alternative-id":["10.1111\/j.1399-6576.2010.02306.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1399-6576.2010.02306.x","archive":["Portico"],"relation":{},"ISSN":["0001-5172","1399-6576"],"issn-type":[{"value":"0001-5172","type":"print"},{"value":"1399-6576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,9,14]]}}}