{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T13:48:45Z","timestamp":1760708925393},"reference-count":15,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2011,8,28]],"date-time":"2011-08-28T00:00:00Z","timestamp":1314489600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"S\u00f6dersjukhuset AB Research Fund"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>General anaesthesia lowers the clearance of crystalloid fluid, but the volume kinetics of such fluid throughout the duration of spinal anaesthesia has not been studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ten female volunteers (mean age 29 years) received an intravenous infusion of 25\u2009ml\/kg of acetated <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>inger's solution with and without spinal anaesthesia. A volume kinetic model was fitted to serial measurements of the haemoglobin concentration over 240\u2009min based on arterial, cubital vein, and femoral vein blood. The measured urine flow was compared to the model\u2010predicted elimination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The arterial pressure remained stable, although the block reached to <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>h3\u2010<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>h5 in half of the volunteers. There were no differences in fluid kinetics between the spinal anaesthesia and the control experiments. The administered volume was well confined to the kinetic system, which consisted of two communicating fluid spaces that were 2.8\u2009l and approximately 7\u2009l in size at baseline. The arteriovenous difference in plasma dilution remained positive for 30\u2009min post\u2010infusion in those having analgesia reaching to <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>h3\u2010<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>h5, which differed significantly from low\u2010level analgesia (<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>h12\u2010<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>2, <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u2009&lt;\u20090.03) when venous plasma was sampled from the leg. The urinary excretion averaged 1.13\u2009l and 1.01\u2009l for the spinal and control experiments, respectively. Volume kinetics predicted the urinary excretion at 5\u2010 to 10\u2010min intervals with an overall bias of 52\u2009ml.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Acetated <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>inger's solution showed the same kinetics during experimental spinal anaesthesia as when the fluid was infused alone. Hence, spinal anaesthesia is not associated with the reduced fluid clearance reported for general anaesthesia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1399-6576.2011.02493.x","type":"journal-article","created":{"date-parts":[[2015,10,13]],"date-time":"2015-10-13T03:24:08Z","timestamp":1444706648000},"page":"987-994","source":"Crossref","is-referenced-by-count":27,"title":["Volume kinetics of acetated <scp>R<\/scp>inger's solution during experimental spinal anaesthesia"],"prefix":"10.1111","volume":"55","author":[{"given":"R. G.","family":"HAHN","sequence":"first","affiliation":[{"name":"Department of Anesthesia at the Faculty of Health Sciences Link\u00f6ping University  Link\u00f6ping Sweden"},{"name":"Research Unit S\u00f6dert\u00e4lje Hospital  S\u00f6dert\u00e4lje Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. C.","family":"LINDAHL","sequence":"additional","affiliation":[{"name":"Department of Anesthesia Karolinska University Hospital  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"DROBIN","sequence":"additional","affiliation":[{"name":"Department of Anesthesia at the Faculty of Health Sciences Link\u00f6ping University  Link\u00f6ping Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,8,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200509000-00006"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000134809.07605.3C"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ane.0000226092.48770.fe"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/80.2.183"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200206000-00016"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.anes.0000268387.34758.6d"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200303000-00015"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2007.01351.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/77.2.223"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/87.3.406"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199901000-00013"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.1987.tb02662.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e3181dcd88f"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1993.73.1.1"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1213\/ane.0b013e31818c95e1"}],"container-title":["Acta Anaesthesiologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1399-6576.2011.02493.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1399-6576.2011.02493.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T14:33:34Z","timestamp":1695479614000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1399-6576.2011.02493.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8,28]]},"references-count":15,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2011,9]]}},"alternative-id":["10.1111\/j.1399-6576.2011.02493.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1399-6576.2011.02493.x","archive":["Portico"],"relation":{},"ISSN":["0001-5172","1399-6576"],"issn-type":[{"value":"0001-5172","type":"print"},{"value":"1399-6576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,8,28]]}}}