{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T05:34:01Z","timestamp":1761975241692},"reference-count":20,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2011,9,8]],"date-time":"2011-09-08T00:00:00Z","timestamp":1315440000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:p>Spina bifida patients have been reported to be at increased risk of anaphylactic reactions during general anaesthesia. Following a reaction, latex is often incriminated as spina bifida patients are known to have an increased incidence of latex allergy. Ethylene oxide (<jats:styled-content style=\"fixed-case\">EO<\/jats:styled-content>) has recently been suggested to be an alternative cause, but in many cases reported in the literature, it seems that <jats:styled-content style=\"fixed-case\">EO<\/jats:styled-content> has not been considered as a cause. <jats:styled-content style=\"fixed-case\">EO<\/jats:styled-content> is a highly reactive gas widely used to sterilise heat\u2010sensitive medical devices, and traces of <jats:styled-content style=\"fixed-case\">EO<\/jats:styled-content> can be found in many of the same products as latex.<\/jats:p><jats:p>We present the case of a spina bifida patient with a known latex allergy, where <jats:styled-content style=\"fixed-case\">EO<\/jats:styled-content> was found to be the cause of an anaphylactic reaction during general anaesthesia. In addition, we describe measures taken during preparation of a subsequent general anaesthesia to minimise exposure to <jats:styled-content style=\"fixed-case\">EO<\/jats:styled-content>.<\/jats:p><jats:p>Spina bifida patients seem to be at increased risk of sensitisation against <jats:styled-content style=\"fixed-case\">EO<\/jats:styled-content> due to repeated exposure, but only limited literature is available. To ensure that <jats:styled-content style=\"fixed-case\">EO<\/jats:styled-content> is considered as a cause in these cases, we recommend that testing for latex and <jats:styled-content style=\"fixed-case\">EO<\/jats:styled-content> go hand in hand following an anaphylactic reaction in this high\u2010risk population.<\/jats:p>","DOI":"10.1111\/j.1399-6576.2011.02504.x","type":"journal-article","created":{"date-parts":[[2011,9,8]],"date-time":"2011-09-08T13:11:59Z","timestamp":1315487519000},"page":"1279-1282","source":"Crossref","is-referenced-by-count":18,"title":["Anaphylaxis to ethylene oxide \u2013 a rare and overlooked phenomenon?"],"prefix":"10.1111","volume":"55","author":[{"given":"S.","family":"BACHE","sequence":"first","affiliation":[{"name":"Department of Anaesthesia Copenhagen University Hospital  Glostrup Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. T.","family":"PETERSEN","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia Copenhagen University Hospital  Glostrup Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. H.","family":"GARVEY","sequence":"additional","affiliation":[{"name":"Danish Anaesthesia Allergy Centre Allergy Clinic KAA\u2010816 Copenhagen University Hospital  Gentofte Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,9,8]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2006.10.014"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200309000-00007"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/87.4.549"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-82-1-58"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1594.1987.tb02640.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199009000-00032"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-998933"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11096-007-9159-2"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.04.029"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(94)90071-X"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(95)70291-1"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(91)90385-2"},{"key":"e_1_2_5_14_1","first-page":"568","article-title":"[3 peroperative anaphylactic accidents due to latex or ethylene oxide]","volume":"38","author":"Mathey C","year":"1990","journal-title":"Cah Anesthesiol"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pec.0000217662.77927.b4"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200008000-00044"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0142-9612(80)90038-1"},{"key":"e_1_2_5_18_1","first-page":"73","article-title":"Determination of gas residuals in ethylene oxide sterilized materials","volume":"4","author":"Handlos V","year":"1976","journal-title":"Arch Pharm Chemi Sci"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2007.01313.x"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.3109\/02688699409002391"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aei198"}],"container-title":["Acta Anaesthesiologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1399-6576.2011.02504.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1399-6576.2011.02504.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T19:16:04Z","timestamp":1695496564000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1399-6576.2011.02504.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9,8]]},"references-count":20,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2011,11]]}},"alternative-id":["10.1111\/j.1399-6576.2011.02504.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1399-6576.2011.02504.x","archive":["Portico"],"relation":{},"ISSN":["0001-5172","1399-6576"],"issn-type":[{"value":"0001-5172","type":"print"},{"value":"1399-6576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,9,8]]}}}