{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T09:57:24Z","timestamp":1696586244178},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,10,14]],"date-time":"2011-10-14T00:00:00Z","timestamp":1318550400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2012,1]]},"abstract":"Introduction<\/jats:title>Recently, low\u2010dose transdermal buprenorphine (LD\u2010TD\u2010BUP<\/jats:styled-content>) was introduced for treatment of patients with chronic non\u2010malignant pain. The primary aim of this study was to determine the proportion of patients who were prescribed LD\u2010TD\u2010BUP<\/jats:styled-content> for non\u2010malignant pain who became long\u2010term users. The secondary aim was to determine the proportion of patients who co\u2010medicated with other opioids or benzodiazepines during treatment with LD\u2010TD\u2010BUP<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>Data were drawn from the N<\/jats:styled-content>orwegian P<\/jats:styled-content>rescription D<\/jats:styled-content>atabase that covers all prescriptions dispensed at pharmacies to the entire N<\/jats:styled-content>orwegian population (4.7\u2009million inhabitants). The study population consisted of all patients who were dispensed at least one prescription of LD\u2010TD\u2010BUP<\/jats:styled-content> from its introduction in N<\/jats:styled-content>ovember 2005 to 31 D<\/jats:styled-content>ecember 2008. Patients who were dispensed more than 24 patches (\u2265\u20096\u2009months) were defined as long\u2010term users. Reimbursement codes were used to stratify patients as having cancer pain or non\u2010malignant pain.<\/jats:p><\/jats:sec>Results<\/jats:title>Among new users of LD\u2010TD\u2010BUP<\/jats:styled-content> for non\u2010malignant pain (n<\/jats:italic>\u2009=\u200913,451), only 22% became long\u2010term users, while 44% were only dispensed one prescription. Among long\u2010term users who were opioid naive when LD\u2010TD\u2010BUP<\/jats:styled-content> was initiated, 43% co\u2010medicated with other opioids or benzodiazepines, compared with 82% of those who previously had used opioids.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Three years after introduction, 0.4% of the N<\/jats:styled-content>orwegian population had been dispensed LD\u2010TD\u2010BUP<\/jats:styled-content>. Only one\u2010fifth had become long\u2010term users. Those who used opioids before the first dispension of LD\u2010TD\u2010BUP<\/jats:styled-content> co\u2010medicated with other potentially addictive drugs to a much higher degree compared with those who were opioid naive.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1399-6576.2011.02537.x","type":"journal-article","created":{"date-parts":[[2011,10,14]],"date-time":"2011-10-14T14:49:39Z","timestamp":1318603779000},"page":"88-94","source":"Crossref","is-referenced-by-count":6,"title":["Low\u2010dose transdermal buprenorphine \u2013 long\u2010term use and co\u2010medication with other potentially addictive drugs"],"prefix":"10.1111","volume":"56","author":[{"given":"A.","family":"NORDB\u00d8","sequence":"first","affiliation":[{"name":"Department of Palliative Medicine Division of Oncology Oslo University Hospital Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"SKURTVEIT","sequence":"additional","affiliation":[{"name":"Department of Pharmacoepidemiology Division of Epidemiology The Norwegian Institute of Public Health Oslo Norway"},{"name":"Norwegian Centre for Addiction Research Faculty of Medicine University of Oslo Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. C.","family":"BORCHGREVINK","sequence":"additional","affiliation":[{"name":"Pain and Palliation Research Group Faculty of Medicine Norwegian University of Science and Technology Trondheim Norway"},{"name":"National Competence Centre for Complex Symptom Disorders St. Olav University Hospital Trondheim Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"KAASA","sequence":"additional","affiliation":[{"name":"Pain and Palliation Research Group Faculty of Medicine Norwegian University of Science and Technology Trondheim Norway"},{"name":"Department of Oncology St. Olav University Hospital Trondheim Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O. 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