{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T22:27:13Z","timestamp":1788215233361,"version":"build-2803163510"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,10,19]],"date-time":"2011-10-19T00:00:00Z","timestamp":1318982400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:p><jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>yasthenia gravis (<jats:styled-content style=\"fixed-case\">MG<\/jats:styled-content>) is a disease affecting the nicotinic acetylcholine receptor of the post\u2010synaptic membrane of the neuromuscular junction, causing muscle fatigue and weakness. The myasthenic patient can be a challenge to anesthesiologists, and the post\u2010surgical risk of respiratory failure has always been a matter of concern. The incidence and prevalence of <jats:styled-content style=\"fixed-case\">MG<\/jats:styled-content> have been increasing for decades and the disease is underdiagnosed. This makes it important for the anesthesiologist to be aware of possible signs of the disease and to be properly updated on the optimal perioperative anesthesiological management of the myasthenic patient. The review is based on electronic searches on <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>ub<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>ed and a review of the references of the articles. The following keywords were used: myasthenia gravis <jats:styled-content style=\"fixed-case\">AND<\/jats:styled-content> neuromuscular blocking agents, myasthenia gravis <jats:styled-content style=\"fixed-case\">AND<\/jats:styled-content> sevoflurane, myasthenia gravis <jats:styled-content style=\"fixed-case\">AND<\/jats:styled-content> epidural, myasthenia gravis <jats:styled-content style=\"fixed-case\">AND<\/jats:styled-content> neuromuscular blockade reversal and myasthenia gravis <jats:styled-content style=\"fixed-case\">AND<\/jats:styled-content> pyridostigmine. The articles included were from reviews and clinical trials written in <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>nglish. <jats:styled-content style=\"fixed-case\">MG<\/jats:styled-content> patients can easily be anesthetized without need for post\u2010surgery mechanical ventilation whether it is general anesthesia or peripheral nerve block. Volatile anesthesia or the use of an epidural for the patient makes it possible to avoid the use of neuromuscular blocking agents, and when used, it should be in smaller doses and the patient should be carefully monitored. This review shows that with thorough pre\u2010operative evaluation, continuing the daily pyridostigmine and careful monitoring the <jats:styled-content style=\"fixed-case\">MG<\/jats:styled-content> patient can be managed safely.<\/jats:p>","DOI":"10.1111\/j.1399-6576.2011.02558.x","type":"journal-article","created":{"date-parts":[[2011,10,19]],"date-time":"2011-10-19T11:35:59Z","timestamp":1319024159000},"page":"17-22","source":"Crossref","is-referenced-by-count":133,"title":["Anesthesia and myasthenia gravis"],"prefix":"10.1111","volume":"56","author":[{"given":"L.","family":"BLICHFELDT\u2010LAURIDSEN","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Sydvestjysk Sygehus Esbjerg  Esbjerg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. 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