{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:56:32Z","timestamp":1790646992048,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,10,19]],"date-time":"2011-10-19T00:00:00Z","timestamp":1318982400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>General anaesthetics can alter the relationship between regional cerebral glucose metabolism rate (<jats:styled-content style=\"fixed-case\">rGMR<\/jats:styled-content>) and regional cerebral blood flow (<jats:styled-content style=\"fixed-case\">rCBF<\/jats:styled-content>). With the present study, we wanted to assess quantitatively the effects of propofol on <jats:styled-content style=\"fixed-case\">rCBF<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">rGMR<\/jats:styled-content> in the same healthy volunteers measured with positron emission tomography (<jats:styled-content style=\"fixed-case\">PET<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\"><jats:sup>15<\/jats:sup>O<\/jats:styled-content>\u2010labelled water and <jats:styled-content style=\"fixed-case\"><jats:sup>18<\/jats:sup>F<\/jats:styled-content> fluorodeoxyglucose were used as <jats:styled-content style=\"fixed-case\">PET<\/jats:styled-content> tracers to determine <jats:styled-content style=\"fixed-case\">rCBF<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">rGMR<\/jats:styled-content>, respectively, in eight healthy volunteers during the waking state (baseline) and during propofol anaesthesia. Propofol was titrated to keep a constant hypnotic depth (<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>ispectral Indes 35\u201340) throughout the anaesthesia. Changes in <jats:styled-content style=\"fixed-case\">rGMR<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">rCBF<\/jats:styled-content> were quantified using region\u2010of\u2010interest and voxel\u2010based analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The measured mean propofol concentration was 4.1\u2009\u00b1\u20090.8\u2009<jats:styled-content style=\"fixed-case\">\u03bcg\/ml<\/jats:styled-content> during anaesthesia. Compared with the conscious state, total <jats:styled-content style=\"fixed-case\">CBF<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">GMR<\/jats:styled-content> decreased during the anaesthetic state with 47% and 54%, respectively. In the white and grey matter, <jats:styled-content style=\"fixed-case\">rCBF<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">rGMR<\/jats:styled-content> were reduced by 37% and 49%, and by 45% and 57%, respectively. Propofol decreased <jats:styled-content style=\"fixed-case\">rCBF<\/jats:styled-content> in all brain structures by 46\u201355% (<jats:styled-content style=\"fixed-case\"><jats:italic>P<\/jats:italic><\/jats:styled-content>\u2009\u2264\u20090.01) with highest significant decreases in the thalamus and parietal lobe. Regional <jats:styled-content style=\"fixed-case\">GMR<\/jats:styled-content> was reduced in all brain areas to 48\u201366% (<jats:styled-content style=\"fixed-case\"><jats:italic>P<\/jats:italic><\/jats:styled-content>\u2009\u2264\u20090.01) with highest significant reductions in the occipital lobe, the lingual gyrus, parietal lobe, temporal lobe and thalamus. No increases in <jats:styled-content style=\"fixed-case\">rCBF<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">rGMR<\/jats:styled-content> happened anywhere.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>General anaesthesia with propofol is associated with a global metabolic and vascular depression in the human brain, with significant shifts in regional blood flow and metabolism indicating marked metabolic and vascular responsiveness in some cortical areas and thalamus.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1399-6576.2011.02561.x","type":"journal-article","created":{"date-parts":[[2011,10,19]],"date-time":"2011-10-19T11:36:05Z","timestamp":1319024165000},"page":"248-255","source":"Crossref","is-referenced-by-count":81,"title":["Regional cerebral blood flow and glucose metabolism during propofol anaesthesia in healthy subjects studied with positron emission tomography"],"prefix":"10.1111","volume":"56","author":[{"given":"L.","family":"SCHL\u00dcNZEN","sequence":"first","affiliation":[{"name":"Department of Neuroanaesthesiology Aarhus University Hospitals  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"JUUL","sequence":"additional","affiliation":[{"name":"Department of Neuroanaesthesiology Aarhus University Hospitals  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. V.","family":"HANSEN","sequence":"additional","affiliation":[{"name":"Department of PET Centre Aarhus University Hospitals  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. E.","family":"COLD","sequence":"additional","affiliation":[{"name":"Department of Neuroanaesthesiology Aarhus University Hospitals  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,10,19]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-13-05506.1999"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0310057X9602400105"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200206000-00015"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200309000-00015"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3260686"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.111164398"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1213\/ane.0b013e31818ffc9d"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/147323000603400406"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/147323000803600618"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2004.00505.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2006.00954.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2009.02181.x"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2010.02208.x"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-199207000-00024"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0173(82)90018-2"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1983.1"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1536-1632(02)00122-1"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00540-006-0411-z"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199009000-00021"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199502000-00010"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e31816d919b"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2001.85.3.1299"},{"key":"e_1_2_5_24_1","first-page":"399","article-title":"Thiopental and propofol affects different regions of the brain at similar pharmacologic effects","volume":"99","author":"Veselis RA","year":"2004","journal-title":"Anesth Analg"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1149213"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2372"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0928-4257(00)01093-7"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(05)50018-9"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeq415"},{"key":"e_1_2_5_30_1","first-page":"2311","article-title":"Relationships among local functional activity, energy metabolism, and blood flow in the central nervous system","volume":"40","author":"Sokoloff L","year":"1981","journal-title":"Fed Proc"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aen036"}],"container-title":["Acta Anaesthesiologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1399-6576.2011.02561.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1399-6576.2011.02561.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T15:39:34Z","timestamp":1695483574000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1399-6576.2011.02561.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10,19]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,2]]}},"alternative-id":["10.1111\/j.1399-6576.2011.02561.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1399-6576.2011.02561.x","archive":["Portico"],"relation":{},"ISSN":["0001-5172","1399-6576"],"issn-type":[{"value":"0001-5172","type":"print"},{"value":"1399-6576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,10,19]]}}}