{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:45:42Z","timestamp":1790790342231,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,12,12]],"date-time":"2011-12-12T00:00:00Z","timestamp":1323648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Constituents of vascular endothelial surface layer (glycocalyx), e.g. an anchor protein syndecan\u20101 (<jats:styled-content style=\"fixed-case\">SDC<\/jats:styled-content>\u20101), can be detected in plasma in many inflammatory conditions. In inflammation, vascular adhesion protein\u20101 (<jats:styled-content style=\"fixed-case\">VAP<\/jats:styled-content>\u20101) is rapidly translocated to the apical side of the endothelial cells and may be released to plasma in a soluble form. We hypothesized that glycocalyx injury coincides with <jats:styled-content style=\"fixed-case\">VAP<\/jats:styled-content>\u20101 activation on endothelial cells. To test the hypothesis, we measured <jats:styled-content style=\"fixed-case\">SDC<\/jats:styled-content>\u20101 and <jats:styled-content style=\"fixed-case\">VAP<\/jats:styled-content>\u20101 levels in 20 patients with septic shock.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective observational study was conducted in two multidisciplinary critical care units in two tertiary academic teaching hospitals with 20 mechanically ventilated adult patients with septic shock, on days 1 and 4 of treatment. Twenty healthy adults were enrolled as a control group. Plasma <jats:styled-content style=\"fixed-case\">SDC<\/jats:styled-content>\u20101 content, serum <jats:styled-content style=\"fixed-case\">VAP<\/jats:styled-content>\u20101 activity, platelets, and leukocyte count were measured in septic shock group at baseline and at 72\u2009h and compared with those of healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">VAP<\/jats:styled-content>\u20101 activity and <jats:styled-content style=\"fixed-case\">SDC<\/jats:styled-content>\u20101 content were significantly increased in septic patients' group (<jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>\u2009<\/jats:italic>&lt;\u20090.01) in comparison with controls. <jats:styled-content style=\"fixed-case\">VAP<\/jats:styled-content>\u20101 activity and <jats:styled-content style=\"fixed-case\">SDC<\/jats:styled-content>\u20101 content correlated positively to each other, and negatively to platelet count. In the septic shock group <jats:styled-content style=\"fixed-case\">SDC<\/jats:styled-content>\u20101 correlated on day 1 to <jats:styled-content style=\"fixed-case\">SOFA<\/jats:styled-content> score.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We found increased <jats:styled-content style=\"fixed-case\">VAP<\/jats:styled-content>\u20101 activity and <jats:styled-content style=\"fixed-case\">SDC<\/jats:styled-content>\u20101 content in critically ill patients with septic shock. Based on our results, the role of <jats:styled-content style=\"fixed-case\">VAP<\/jats:styled-content>\u20101 in shock pathogenesis should be studied with semicarbazide\u2010sensitive amine oxidase activity blocking agents and substrate affinity testing.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1399-6576.2011.02578.x","type":"journal-article","created":{"date-parts":[[2011,12,12]],"date-time":"2011-12-12T18:09:23Z","timestamp":1323713363000},"page":"316-322","source":"Crossref","is-referenced-by-count":89,"title":["Vascular adhesion protein\u20101 and syndecan\u20101 in septic shock"],"prefix":"10.1111","volume":"56","author":[{"given":"M.","family":"SALLISALMI","sequence":"first","affiliation":[{"name":"Intensive Care Units Division of Anaesthesia and Intensive Care Medicine Helsinki University Hospital  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"TENHUNEN","sequence":"additional","affiliation":[{"name":"Critical Care Medicine 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