{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:48:14Z","timestamp":1772160494066,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,1,31]],"date-time":"2012-01-31T00:00:00Z","timestamp":1327968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2012,7]]},"abstract":"\n Background<\/jats:title>\n \n Dose requirements of thiopental depend on patient characteristics and infusion rate. We determined thiopental dose requirements for induction of anaesthesia, and the effects of remifentanil on cardiovascular and bispectral index (\n BIS<\/jats:styled-content>\n ) responses to tracheal intubation in spinal cord\u2010injured (\n SCI<\/jats:styled-content>\n ) patients undergoing general anaesthesia.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Twenty patients with traumatic complete\n SCI<\/jats:styled-content>\n undergoing elective surgery were enrolled. Twenty patients without\n SCI<\/jats:styled-content>\n served as control. Anaesthesia was induced with thiopental, followed by remifentanil 1\u2009\n \u03bc<\/jats:italic>\n g\/kg and rocuronium 0.8\u2009mg\/kg, and maintained with 2% sevoflurane and 50% nitrous oxide in oxygen after tracheal intubation. Thiopental was administered at a rate of 50\u2009mg\/15\u2009s until abolition of the eyelash reflex. Thiopental doses,\n BIS<\/jats:styled-content>\n values, systolic arterial blood pressure (\n SAP<\/jats:styled-content>\n ), heart rate (\n HR<\/jats:styled-content>\n ) and plasma catecholamine concentrations were measured.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Total thiopental dose required to abolish the eyelash reflex based on total body weight (\n BW<\/jats:styled-content>\n ) (5.26\u2009\u00b1\u20090.87 vs. 3.91\u2009\u00b1\u20091.07\u2009mg\/kg,\n \n P<\/jats:styled-content>\n <\/jats:italic>\n \u2009<\u20090.001) or lean\n BW<\/jats:styled-content>\n (6.56\u2009\u00b1\u20091.37 vs. 5.24\u2009\u00b1\u20091.36\u2009mg\/kg,\n \n P<\/jats:styled-content>\n <\/jats:italic>\n \u2009<\u20090.01) were significantly smaller in the\n SCI<\/jats:styled-content>\n group than in the control.\n SAP<\/jats:styled-content>\n was decreased by induction of anaesthesia with thiopental and remifentanil, and increased by tracheal intubation in both groups. However, the peak\n SAP<\/jats:styled-content>\n after intubation was smaller in the\n SCI<\/jats:styled-content>\n patients.\n HR<\/jats:styled-content>\n increased significantly above baseline values following intubation in both groups with no significant intergroup differences. Hypertension was more frequent in the control group. Norepinephrine concentrations remained unaltered following intubation in both groups.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n These results suggest that the dose requirements of thiopental for induction of general anaesthesia and subsequent tracheal intubation are reduced in the\n SCI<\/jats:styled-content>\n patients.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/j.1399-6576.2011.02640.x","type":"journal-article","created":{"date-parts":[[2012,1,31]],"date-time":"2012-01-31T05:37:08Z","timestamp":1327988228000},"page":"770-776","source":"Crossref","is-referenced-by-count":2,"title":["Thiopental dose requirements for induction of anaesthesia and subsequent endotracheal intubation in patients with complete spinal cord injuries"],"prefix":"10.1111","volume":"56","author":[{"given":"K. Y.","family":"YOO","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology and Pain Medicine Chonnam National University Medical School Gwangju South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. W.","family":"JEONG","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Pain Medicine Chonnam National University Medical School Gwangju South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. J.","family":"JEONG","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Pain Medicine Chonnam National University Medical School Gwangju South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. H.","family":"LEE","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Pain Medicine Chonnam National University Medical School Gwangju South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. H.","family":"NA","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Seonam University Hospital Gwangju South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. J.","family":"KIM","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Pain Medicine Chonnam National University Medical School Gwangju South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. T.","family":"JEONG","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Pain Medicine Chonnam National University Medical School Gwangju South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"LEE","sequence":"additional","affiliation":[{"name":"Department of Physiology Chonnam National University Medical School Gwangju South 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